White J M, Richards R, Byrne M, Buchanan T, White Y S, Jelenski G
J Clin Pathol. 1985 Jul;38(7):810-7. doi: 10.1136/jcp.38.7.810.
The haematological variables, haematinic state, and placental function of more than 2000 pregnant women, heterozygous for either alpha- or beta-thalassaemia genes, were examined during pregnancy. Four features emerged. Firstly, it was possible by discriminant function analysis of haematological variables to distinguish in pregnant patients between the anaemia caused by thalassaemia trait and that caused by iron deficiency. Secondly, patients with thalassaemia become significantly more anaemic in pregnancy, beta more than alpha, but this was mainly due to plasma dilution. From the data percentile curves were drawn for each type of thalassaemia which predicted the patients' expected "normal" haemoglobin throughout gestation. Thirdly, patients with alpha-thalassaemia had the same incidence of iron deficiency as normal pregnant patients, whereas in those with beta-thalassaemia it was four times less common. The incidence of folic acid and vitamin B12 deficiency was the same in all groups. Finally, as assessed by serum oestriol concentration, there did not appear to be any abnormality of placental function or fetal development associated with maternal thalassaemia, and, also, there seemed to be no increase in maternal or fetal morbidity in pregnancy.
对2000多名携带α或β地中海贫血基因杂合子的孕妇在孕期的血液学变量、造血状态和胎盘功能进行了检查。出现了四个特征。首先，通过对血液学变量进行判别函数分析，有可能在孕妇中区分地中海贫血特质引起的贫血和缺铁引起的贫血。其次，地中海贫血患者在孕期贫血明显加重，β型比α型更严重，但这主要是由于血浆稀释。根据数据为每种类型的地中海贫血绘制了百分位数曲线，这些曲线预测了患者整个孕期预期的“正常”血红蛋白水平。第三，α地中海贫血患者缺铁的发生率与正常孕妇相同，而β地中海贫血患者缺铁的发生率则低四倍。所有组中叶酸和维生素B12缺乏的发生率相同。最后，通过血清雌三醇浓度评估，似乎没有与母亲地中海贫血相关的胎盘功能或胎儿发育异常，而且孕期母亲或胎儿的发病率似乎也没有增加。
