Thanthrige Nipuni, Bhowmik Sudipta Das, Williams Brett
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Centre for Agriculture and the Bioeconomy, Queensland University of Technology, Brisbane, Australia.
FEBS Lett. 2025 Mar;599(5):645-655. doi: 10.1002/1873-3468.15062. Epub 2024 Nov 24.
Autophagy is a genetically regulated, eukaryotic catabolic pathway that responds to internal and external cellular signals. In plants, it plays crucial roles in development, and responses to abiotic and biotic stresses. Due to its role in limiting the hypersensitive response, research on the molecular mechanisms of autophagic signalling pathways in plant-microbe interactions has primarily focused on plant-pathogen responses. Although there is substantially less information on the role of autophagy signalling in symbiotic plant-microbe interactions, there is accumulating evidence that it is also a key regulator of mutualistic plant-microbe interactions. Here, we review recent progress on the roles of autophagy in symbiotic plant interactions and discuss potential future research directions. Once understood, the central role that autophagy plays within pathogenic and symbiotic plant-microbe interactions has significant potential application for crop improvement. Manipulating autophagy in legume crops could help support crop growth with reduced levels of fertiliser application while maintaining yields with increased protein content in the harvest.
自噬是一种受基因调控的真核细胞分解代谢途径，可响应细胞内部和外部信号。在植物中，它在发育以及对非生物和生物胁迫的响应中发挥着关键作用。由于其在限制超敏反应中的作用，植物-微生物相互作用中自噬信号通路的分子机制研究主要集中在植物-病原体反应上。尽管关于自噬信号在共生植物-微生物相互作用中的作用的信息要少得多，但越来越多的证据表明，它也是互利共生植物-微生物相互作用的关键调节因子。在这里，我们综述了自噬在共生植物相互作用中的作用的最新进展，并讨论了未来潜在的研究方向。一旦了解，自噬在致病和共生植物-微生物相互作用中所起的核心作用在作物改良方面具有重大的潜在应用价值。操纵豆科作物中的自噬可以帮助在减少肥料施用量的情况下支持作物生长，同时在收获时保持产量并提高蛋白质含量。
