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The emergence of inhalable RNA therapeutics and challenges faced - where to from here?

作者信息

Haque Shadabul, Kaminskas Lisa M

机构信息

Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

出版信息

Nanomedicine (Lond). 2025 Feb;20(3):251-253. doi: 10.1080/17435889.2024.2429368. Epub 2024 Nov 24.

DOI:10.1080/17435889.2024.2429368
PMID:39582281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11792789/
Abstract
摘要

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本文引用的文献

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Recent Progress in Nucleic Acid Pulmonary Delivery toward Overcoming Physiological Barriers and Improving Transfection Efficiency.核酸肺部递呈技术克服生理屏障并提高转染效率的最新进展。
Adv Sci (Weinh). 2024 May;11(18):e2309748. doi: 10.1002/advs.202309748. Epub 2024 Mar 9.
2
Recent advances in nanoparticulate RNA delivery systems.纳米颗粒 RNA 递释系统的最新进展。
Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307798120. doi: 10.1073/pnas.2307798120. Epub 2024 Mar 4.
3
Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol.雾化 RNA 制剂递送至肺部：从气溶胶到细胞质。
J Control Release. 2024 Feb;366:812-833. doi: 10.1016/j.jconrel.2023.12.012. Epub 2024 Jan 25.
4
Inhaled RNA drugs to treat lung diseases: Disease-related cells and nano-bio interactions.吸入式 RNA 药物治疗肺部疾病：与疾病相关的细胞和纳-生物相互作用。
Adv Drug Deliv Rev. 2023 Dec;203:115144. doi: 10.1016/j.addr.2023.115144. Epub 2023 Nov 22.
5
Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats.大鼠体内临床相关脂质纳米颗粒引发的聚乙二醇（PEG）相关免疫反应。
NPJ Vaccines. 2023 Nov 2;8(1):169. doi: 10.1038/s41541-023-00766-z.
6
Development of lung tissue models and their applications.肺组织模型的开发及其应用。
Life Sci. 2023 Dec 1;334:122208. doi: 10.1016/j.lfs.2023.122208. Epub 2023 Oct 24.
7
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications.用于体内 RNA 递送的脂质纳米颗粒 (LNPs) 及其未来应用的突破性技术。
Adv Drug Deliv Rev. 2023 Sep;200:114990. doi: 10.1016/j.addr.2023.114990. Epub 2023 Jul 7.
8
Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates.iSEND 纳米粒递呈的地塞米松经吸入途径给药可减轻 COVID-19 小鼠和非人灵长类动物的细胞因子风暴。
Sci Adv. 2023 Jun 16;9(24):eadg3277. doi: 10.1126/sciadv.adg3277. Epub 2023 Jun 14.
9
Liposomes are Poorly Absorbed Lung Lymph After Inhaled Administration in Sheep.脂质体经吸入给药后在绵羊肺部淋巴中的吸收较差。
Front Pharmacol. 2022 Jun 2;13:880448. doi: 10.3389/fphar.2022.880448. eCollection 2022.
10
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Exp Mol Med. 2022 Apr;54(4):455-465. doi: 10.1038/s12276-022-00757-5. Epub 2022 Apr 19.