Liu Xuefeng, Liu Yuedong, Shu Yuping, Tao Hongwu, Sheng Zewei, Peng Yuyu, Cai Meiqi, Zhang Xiaoming, Lan Weiru
Liaoning University of Traditional Chinese Medicine, Second Clinical College, Shenyang, China.
Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Front Nutr. 2024 Nov 8;11:1483515. doi: 10.3389/fnut.2024.1483515. eCollection 2024.
Numerous studies have suggested a link between dietary micronutrient intake and the onset of constipation. Nevertheless, there has not been much research done on the potential relationship between vitamin B6 and constipation. The purpose of this study was to determine whether dietary vitamin B6 consumption and chronic constipation are related among adult participants in the National Health and Nutrition Examination Survey (NHANES).
The study made use of information from the 2009-2010 NHANES health and nutrition survey. Respondents' dietary information was gathered using 24-h dietary recalls. A range of statistical techniques, including as interaction tests, subgroup analyses, and curve fitting analyses, were used to examine the connection between dietary vitamin B6 intake and chronic constipation.
This study included 3,643 patients, with 270 (7.41%) diagnosed with persistent constipation. A fully adjusted multiple logistic regression analysis found that increasing dietary vitamin B6 consumption (OR = 0.78, 95% CI: 0.68-0.89) was linked to a lower incidence of constipation, with significance at < 0.05. After accounting for numerous factors, the odds ratio and 95% confidence interval for the third tertile compared to the reference group (first tertile) were 0.85 (0.74, 0.98), with statistical significance at < 0.05. Furthermore, subgroup analysis and interaction assessments revealed a substantial negative link between vitamin B6 intake and the occurrence of constipation, particularly in males and alcohol drinkers (all -values were less than 0.05).
This study found an inverse connection between vitamin B6 consumption and the prevalence of persistent constipation. More extensive prospective trials are needed to fully examine the long-term influence of vitamin B6 on persistent constipation.
众多研究表明饮食中微量营养素的摄入与便秘的发生之间存在联系。然而，关于维生素B6与便秘之间的潜在关系，尚未开展太多研究。本研究的目的是确定在国家健康与营养检查调查（NHANES）的成年参与者中，饮食中维生素B6的摄入量与慢性便秘是否相关。
本研究利用了2009 - 2010年NHANES健康与营养调查的信息。通过24小时饮食回顾收集受访者的饮食信息。使用了一系列统计技术，包括交互作用测试、亚组分析和曲线拟合分析，来研究饮食中维生素B6摄入量与慢性便秘之间的联系。
本研究纳入了3643名患者，其中270名（7.41%）被诊断为持续性便秘。一项完全调整的多因素逻辑回归分析发现，饮食中维生素B6摄入量的增加（OR = 0.78，95%CI：0.68 - 0.89）与便秘发生率较低相关，差异有统计学意义（P < 0.05）。在考虑了众多因素后，与参考组（第一三分位数）相比，第三三分位数的比值比和95%置信区间为0.85（0.74，0.98），差异有统计学意义（P < 0.05）。此外，亚组分析和交互作用评估显示维生素B6摄入量与便秘的发生之间存在显著的负相关，尤其是在男性和饮酒者中（所有P值均小于0.05）。
本研究发现维生素B6摄入量与持续性便秘的患病率之间存在负相关。需要更广泛的前瞻性试验来全面研究维生素B6对持续性便秘的长期影响。
