Li Xinran, Bian Conghui, Dai Hui, Chen Xingrui, Qian Haihua, Zhang Dan
The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.
BMC Gastroenterol. 2025 Jan 22;25(1):31. doi: 10.1186/s12876-024-03575-3.
Constipated patients may exhibit anxious behaviors, but the relationship between the two remains unclear. This population-based study aims to investigate the relationships of anxiety status and anxiety duration with constipation among U.S. adults.
Using data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2007 to 2010, a cross-sectional study included 8945 participants was performed to assess the relationships of anxiety status and anxiety duration with constipation. Participants' characteristics were presented using mean or proportion. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression models. The analysis accounted for potential confounding factors, including gender, age, race/ethnicity, education level, marital status, PIR, BMI, smoking status, drinking status, chronic diseases, and dietary intake. Subgroup analyses were conducted to ensure the stability of the results. Smoothed curve fitting was applied to investigate both linear and nonlinear associations between anxiety duration and constipation risk. Threshold effects were assessed using two-piecewise linear regression models.
Of the 8945 participants, 922 reported constipation, with a prevalence of 10.3%. After adjusting for confounding factors, individuals with anxiety status exhibited an increased risk of constipation (OR: 1.49, 95% CI: 1.28-1.73). Stratified analyses indicated that the association between anxiety status and constipation remained relatively stable across different stratification levels. Smoothed curve fitting and threshold effect analyses revealed a linear association between anxiety duration and constipation among adults aged 20-60, while a nonlinear inverted U-shaped relationship was observed in those aged 60 and older, with an inflection point at 10 days. The two variables correlated positively on the left side of the inflection point but not on the right.
This study showed that a significant association between anxiety status and constipation among U.S. adults. Additionally, an age-dependent association between anxiety duration and constipation was observed, particularly among individuals aged 60 and older.
便秘患者可能表现出焦虑行为，但两者之间的关系仍不明确。这项基于人群的研究旨在调查美国成年人中焦虑状态和焦虑持续时间与便秘之间的关系。
利用2007年至2010年国家健康与营养检查调查（NHANES）数据库的数据，进行了一项横断面研究，纳入8945名参与者，以评估焦虑状态和焦虑持续时间与便秘之间的关系。参与者的特征用均值或比例表示。使用多变量逻辑回归模型计算调整后的比值比（OR）和95%置信区间（CI）。分析考虑了潜在的混杂因素，包括性别、年龄、种族/民族、教育水平、婚姻状况、贫困收入比、体重指数、吸烟状况、饮酒状况、慢性病和饮食摄入。进行亚组分析以确保结果的稳定性。应用平滑曲线拟合来研究焦虑持续时间与便秘风险之间的线性和非线性关联。使用两段式线性回归模型评估阈值效应。
在8945名参与者中，922人报告有便秘，患病率为10.3%。在调整混杂因素后，有焦虑状态的个体便秘风险增加（OR：1.49，95%CI：1.28 - 1.73）。分层分析表明，焦虑状态与便秘之间的关联在不同分层水平上相对稳定。平滑曲线拟合和阈值效应分析显示，20 - 60岁成年人中焦虑持续时间与便秘之间存在线性关联，而60岁及以上人群中观察到非线性倒U形关系，拐点在10天。在拐点左侧两个变量呈正相关，右侧则不然。
这项研究表明美国成年人中焦虑状态与便秘之间存在显著关联。此外，观察到焦虑持续时间与便秘之间存在年龄依赖性关联，尤其是在60岁及以上的个体中。
