Wang Chao, Li Bo, Zhu Qian, Zhang Qikeng, Xie Zhenyan, Xie Huixi, Li Xuesong
Department of Neurosurgery, Huizhou Third People's Hospital, Huizhou Hospital Affiliated to Guangzhou Medical University, Huizhou, China.
Department of Neurosurgery, The First Clinical Medical College, Guangdong Medical University, Zhanjiang, China.
Heliyon. 2024 May 11;10(10):e31125. doi: 10.1016/j.heliyon.2024.e31125. eCollection 2024 May 30.
The relationship between dietary vitamin B6 and stroke risk is controversial; thus, we analyzed their correlation using data from the National Health and Nutrition Examination Survey (NHANES).
Data from 2005 to 2018 were collected from the NHANES database. Two 24-h dietary recalls and a standard questionnaire were used to evaluate vitamin B6 intake and stroke prevalence. We used logistic regression models to estimate the association between dietary vitamin B6 intake and stroke risk and investigated the nonlinear relationship between them using a restricted cubic spline (RCS). Sensitivity analysis was conducted using propensity score matching (PSM).
Among 24,214 participants, 921 were patients diagnosed with stroke, while 23,293 were without stroke. The multivariate logistic regression model revealed that individuals in the highest quartile of vitamin B6 consumption had a significantly lower stroke risk than those in the lowest quartile under the fully adjusted model (OR: 0.48, 95 % CI: 0.35-0.66, < 0.001). Subgroup analyses showed that dietary intake of vitamin B6 was a significant protective factor against stroke risk in different populations, with the most pronounced effect in the population engaging in moderate-intensity physical activity (OR: 0.34, 95%CI: 0.20-0.57). The RCS models revealed a non-linear L-shaped relationship (P for nonlinearity = 0.006) between stroke and dietary intake of vitamin B6.
Our study shows that an increased intake of vitamin B6 could be an effective strategy in reducing the risk of stroke.
饮食中维生素B6与中风风险之间的关系存在争议；因此，我们使用美国国家健康与营养检查调查（NHANES）的数据来分析它们之间的相关性。
从NHANES数据库收集2005年至2018年的数据。使用两次24小时饮食回忆和一份标准问卷来评估维生素B6摄入量和中风患病率。我们使用逻辑回归模型来估计饮食中维生素B6摄入量与中风风险之间的关联，并使用受限立方样条（RCS）研究它们之间的非线性关系。使用倾向得分匹配（PSM）进行敏感性分析。
在24,214名参与者中，921名被诊断为中风患者，而23,293名没有中风。多变量逻辑回归模型显示，在完全调整模型下，维生素B6摄入量最高四分位数的个体中风风险显著低于最低四分位数的个体（OR：0.48，95%CI：0.35-0.66，P<0.001）。亚组分析表明，饮食中维生素B6的摄入量是不同人群中风风险的重要保护因素，在进行中等强度体育活动的人群中效果最为显著（OR：0.34，95%CI：0.20-0.57）。RCS模型显示中风与饮食中维生素B6摄入量之间存在非线性L形关系（非线性P=0.006）。
我们的研究表明，增加维生素B6的摄入量可能是降低中风风险的有效策略。
