Lu Wanhang, Chen Qingqing, Wu Xiaomin, Li Jiaqi, Li Ming, Xiao Yongkang, Gong Lei, Sun Yong
Anhui Provincial Center for Disease Control and Prevention, Hefei City, Anhui Province, China.
China CDC Wkly. 2024 Nov 15;6(46):1218-1222. doi: 10.46234/ccdcw2024.245.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Monkeypox, first identified in Africa in 1958, is a zoonotic disease caused by monkeypox virus (MPXV). Since January 2022, a global outbreak of mpox has spread to over 100 non-endemic countries. As of June 30, 2024, there have been 99,176 confirmed cases and 535 probable cases across 116 countries, resulting in 208 deaths.
WHAT IS ADDED BY THIS REPORT?: This report presents an analysis of the whole genome sequences of seven MPXVs from Anhui Province. We discovered that, compared to the reference sequence (NC_063383.1), these genomes exhibit 91 nucleotide substitutions and 42 amino acid mutations. They are highly similar to genomes of MPXVs that emerged simultaneously in China, Japan, the Republic of Korea, and Portugal, and are classified within the IIb C.1.1 lineage, with multiple transmission chains and no new branch.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: The MPXV in Anhui Province has undergone mutations in areas critical for viral replication, transcription, and immune escape, posing a risk of recurrent outbreaks. Therefore, vigilant mutation monitoring of MPXV is imperative.
关于该主题已知的信息有哪些？：猴痘于1958年在非洲首次被发现，是一种由猴痘病毒（MPXV）引起的人畜共患病。自2022年1月以来，猴痘全球疫情已蔓延至100多个非流行国家。截至2024年6月30日，116个国家报告了99176例确诊病例和535例疑似病例，导致208人死亡。
本报告补充了哪些内容？：本报告对来自安徽省的7株猴痘病毒全基因组序列进行了分析。我们发现，与参考序列（NC_063383.1）相比，这些基因组存在91个核苷酸替换和42个氨基酸突变。它们与在中国、日本、韩国和葡萄牙同时出现的猴痘病毒基因组高度相似，属于IIb C.1.1分支，存在多个传播链且无新分支。
对公共卫生实践有何启示？：安徽省的猴痘病毒在病毒复制、转录和免疫逃逸的关键区域发生了突变，存在再次爆发的风险。因此，必须对猴痘病毒进行密切的突变监测。
