Ji Xingpei, Liang Ruyue, Bao Chao, Cai Xiuli, Chen Shiyao, Chen Lu, Li Li, Ji Xiaolei
Key Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Virol J. 2024 Dec 23;21(1):334. doi: 10.1186/s12985-024-02616-3.
Monkeypox (MPOX) is a zoonotic disease caused by Orthopoxvirus monkeypox (MPXV), belonging to the Orthopoxvirus genus, and exhibits symptoms similar to smallpox. In 2024, the monkeypox outbreak in the Democratic Republic of the Congo continued to develop, raising widespread global public health concerns. In September 2023, the first local monkeypox outbreak was reported in Nantong, Jiangsu Province, China. Whole-genome sequencing of samples from seven confirmed patients identified a new lineage, C.1.1, which may be related to imported cases from Japan. Evolutionary analysis of MPXV showed fewer mutations mediated by Apolipoprotein B mRNA Editing Catalytic polypeptide-like 3 (APOBEC3). Additionally, mutations in the N2L protein disrupted transcription initiation, while changes in the Cytomegalovirus-encoded immunomodulatory protein B (CrmB) led to structural instability of the protein. It is hoped that these findings will provide insights for future research on the evolutionary mechanisms of the monkeypox virus and the development of vaccines.
猴痘（MPOX）是一种由猴痘病毒（MPXV）引起的人畜共患病，猴痘病毒属于正痘病毒属，其症状与天花相似。2024年，刚果民主共和国的猴痘疫情持续发展，引发了全球广泛的公共卫生关注。2023年9月，中国江苏省南通市报告了首例本地猴痘疫情。对7例确诊患者样本的全基因组测序确定了一个新的谱系C.1.1，这可能与来自日本的输入病例有关。猴痘病毒的进化分析表明，载脂蛋白B mRNA编辑催化多肽样3（APOBEC3）介导的突变较少。此外，N2L蛋白中的突变破坏了转录起始，而巨细胞病毒编码的免疫调节蛋白B（CrmB）的变化导致了该蛋白的结构不稳定。希望这些发现将为未来猴痘病毒进化机制的研究和疫苗开发提供见解。
