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急性肾损伤的新方法。

New approaches to acute kidney injury.

作者信息

Noel Sanjeev, Kapoor Radhika, Rabb Hamid

机构信息

Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

出版信息

Clin Kidney J. 2024 Nov 22;17(Suppl 2):65-81. doi: 10.1093/ckj/sfae265. eCollection 2024 Dec.

DOI:10.1093/ckj/sfae265
PMID:39583139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11581771/
Abstract

Acute kidney injury (AKI) is a common and serious clinical syndrome that involves complex interplay between different cellular, molecular, metabolic and immunologic mechanisms. Elucidating these pathophysiologic mechanisms is crucial to identify novel biomarkers and therapies. Recent innovative methodologies and the advancement of existing technologies has accelerated our understanding of AKI and led to unexpected new therapeutic candidates. The aim of this review is to introduce and update the reader about recent developments applying novel technologies in omics, imaging, nanomedicine and artificial intelligence to AKI research, plus to provide examples where this can be translated to improve patient care.

摘要

急性肾损伤（AKI）是一种常见且严重的临床综合征，涉及不同细胞、分子、代谢和免疫机制之间的复杂相互作用。阐明这些病理生理机制对于识别新型生物标志物和治疗方法至关重要。最近的创新方法和现有技术的进步加速了我们对AKI的理解，并催生了意想不到的新治疗候选物。本综述的目的是向读者介绍并更新在组学、成像、纳米医学和人工智能等新技术应用于AKI研究方面的最新进展，并提供可以转化为改善患者护理的实例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/d7a6382902f4/sfae265fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/064cfd19c0b5/sfae265fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/7e63f7760e58/sfae265fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/de5d9aa4bd92/sfae265fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/f78ac81908da/sfae265fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/a38ab13194d0/sfae265fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/d7a6382902f4/sfae265fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/064cfd19c0b5/sfae265fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/7e63f7760e58/sfae265fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/de5d9aa4bd92/sfae265fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/f78ac81908da/sfae265fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/a38ab13194d0/sfae265fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa9e/11581771/d7a6382902f4/sfae265fig6.jpg

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引用本文的文献

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Front Mol Biosci. 2025 Aug 20;12:1643838. doi: 10.3389/fmolb.2025.1643838. eCollection 2025.
2
Transition from acute kidney injury to chronic kidney disease in liver cirrhosis patients: Current perspective.肝硬化患者急性肾损伤向慢性肾脏病的转变：当前观点
World J Nephrol. 2025 Mar 25;14(1):102381. doi: 10.5527/wjn.v14.i1.102381.