亚急性硬化性全脑炎患者的显著改善：一例不寻常病例报告。
Substantial Improvement in a Patient with Subacute Sclerosing Panencephalitis: An Unusual Case Report.
机构信息
Department of Neurology, King George's Medical University, Lucknow, India.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2024 Nov 21;14:57. doi: 10.5334/tohm.972. eCollection 2024.
BACKGROUND
Subacute Sclerosing Panencephalitis (SSPE) is a fatal disorder marked by gradual cognitive and motor deterioration, leading to death typically within 1-3 years.
CASE REPORT
A 20-year-old woman with progressive abnormal behaviour, forgetfulness, and involuntary movements showed significant improvement after treatment with interferon and isoprinosine. Initially severely cognitively impaired and dependent, she regained independence and demonstrated marked cognitive enhancement, her MMSE improved from 15 to 28 and reduced myoclonus. Her progress was sustained over three years, substantially enhancing her quality of life.
DISCUSSION
This SSPE case shows significant improvement in disability. Early identification of such cases is crucial for improved prognostic counselling for families.
背景
亚急性硬化性全脑炎（SSPE）是一种致命疾病，其特征为认知和运动功能逐渐恶化，通常在 1-3 年内导致死亡。
病例报告
一名 20 岁女性，出现进行性异常行为、健忘和不自主运动，经干扰素和异丙肌苷治疗后显著改善。最初严重认知障碍和依赖，她恢复了独立性，并表现出明显的认知增强，她的 MMSE 从 15 提高到 28，肌阵挛减少。她的病情持续了三年，极大地提高了她的生活质量。
讨论
这个 SSPE 病例显示出残疾的显著改善。早期识别此类病例对于改善家庭预后咨询至关重要。
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