Choline Chloride-Urea Deep Eutectic Solvent/Cu-Mn Iminodiacetate Coordination Polymer as an Efficient Catalytic System for Synthesis of Morita-Baylis-Hillman Adducts with Antimicrobial Activity.

This work shows the synthesis of a series of Morita-Baylis-Hillman adducts from isatin derivatives via an efficient green approach involving the use of a new catalyst system, a mixture of copper-manganese iminodiacetate 1D coordination polymer (Cu/Mn-IDA) and choline chloride-urea deep eutectic solvent (ChCl/urea 1:2). The adducts were obtained in good to excellent yields (59-97%) with shorter reaction times. The results demonstrate for the first time the synergistic catalytic effect of the combination of deep eutectic solvent and coordination polymer on the Morita-Baylis-Hillman reactions. The catalyst recyclability was investigated, and it was found that Cu/Mn-IDA maintains consistent performance for at least four catalytic cycles. The synthesized compounds were evaluated for their in vitro antimicrobial activity against four bacteria and eight fungi species. Among all, , , , , and showed antifungal and antibacterial activities in 70-83% of the strains tested. The adduct exhibited significant antifungal activity with a minimum inhibitory concentration value of 128 μg mL compared to the standard drug fluconazole (minimum inhibitory concentration, 256 μg mL).