Shimizu Kaori, Kuramochi Yui, Hayamizu Kohsuke
Department of Pharmacy, Yokohama University of Pharmacy, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
J Clin Biochem Nutr. 2024 Nov;75(3):204-212. doi: 10.3164/jcbn.24-36. Epub 2024 Aug 9.
Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) have been reported to improve sleep quality in several studies, but meta-analyses have been inconclusive. We conducted this study to investigate the effects of omega-3 LC-PUFAs on sleep in clinical trials. The study was planned in accordance with the criteria of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-2020), and was performed by searching PubMed, The Cochrane Library, and Ichushi-web databases. Randomized controlled trials and clinical trials with control groups were included. Finally, eight studies were selected for inclusion in this study. Sleep efficiency was significantly higher in the omega-3 LC-PUFA group than in the control group, while sleep latency and total sleep duration did not differ significantly. Subjectively assessed sleep was significantly improved by omega-3 LC-PUFA, but heterogeneity was so high that a subgroup analysis based on dose of omega-3 supplementation was performed. It showed low heterogeneity and significant improvement in the omega-3 LC-PUFA group compared with the control group. Omega-3 LC-PUFAs have been shown to may improve sleep quality. Further studies are needed to confirm the relationship between omega-3 LC-PUFAs and sleep. The protocol for this review was registered in UMIN000052527.
多项研究报告称，ω-3长链多不饱和脂肪酸（LC-PUFA）可改善睡眠质量，但荟萃分析尚无定论。我们开展本研究以调查ω-3 LC-PUFA在临床试验中对睡眠的影响。本研究按照系统评价与荟萃分析方案优先报告条目（PRISMA-2020）的标准进行规划，并通过检索PubMed、考克兰图书馆和日本医学中央杂志网络数据库来开展。纳入随机对照试验和有对照组的临床试验。最终，选择八项研究纳入本研究。ω-3 LC-PUFA组的睡眠效率显著高于对照组，而睡眠潜伏期和总睡眠时间无显著差异。ω-3 LC-PUFA可显著改善主观评估的睡眠，但异质性过高，因此基于ω-3补充剂量进行了亚组分析。结果显示，与对照组相比，ω-3 LC-PUFA组异质性较低且有显著改善。已表明ω-3 LC-PUFA可能改善睡眠质量。需要进一步研究来证实ω-3 LC-PUFA与睡眠之间的关系。本综述方案已在UMIN000052527中注册。
