在组织学确诊为脂肪性肝病的青少年中，血清内脂素水平未发生改变。

Serum adropin is unaltered in adolescents with histology-confirmed steatotic liver disease.

作者信息

Bays Jordan A, Bartlett Alyssa M, Boone Alison M, Kim Youngsil, Yu Zhongxin, Palle Sirish K, Short Kevin R

机构信息

Section of Diabetes/Endocrinology, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

出版信息

J Pediatr Gastroenterol Nutr. 2025 Jan;80(1):182-188. doi: 10.1002/jpn3.12423. Epub 2024 Nov 25.

DOI:10.1002/jpn3.12423

PMID:39584317

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11874941/

Abstract

OBJECTIVES

Metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents is increasing. Adropin is a liver-derived peptide involved in glucose and lipid homeostasis that was shown to be reduced in adults with metabolic disorders and cardiovascular disease (CVD). Serum adropin may also be higher in young men than women. A prior study reported that serum adropin was reduced in adolescents with MASLD, but the relationship between liver histology and CVD risk factors was not reported. We tested the hypotheses that adropin is (1) reduced in adolescents with MASLD compared to adolescents with obesity (Ob) or normal weight (NW) without MASLD, (2) correlated with blood pressure (BP), arterial stiffness, and liver histopathology, and (3) higher in boys than girls.

METHODS

Serum adropin was measured in 47 patients with MASLD, and 27 and 29 control participants with Ob or NW, respectively.

RESULTS

Adropin was not reduced but was instead 5% and 20% higher (p > 0.42) in the MASLD compared to the Ob and NW groups, respectively. Adropin concentration was not correlated with arterial stiffness or BP. Adropin was 20% higher in boys than girls in the entire study cohort (p = 0.034). This difference was evident in the Ob group (p = 0.018), but not in the NW (p = 0.537) or the MASLD (p = 0.893) groups. Adropin was positively correlated with age within the MASLD group only (r = 0.46, p < 0.001).

CONCLUSION

Serum adropin was not reduced in adolescents with Ob or MASLD as reported previously. The positive relationship between age and adropin in adolescents with MASLD requires further examination.

摘要

目的

青少年代谢功能障碍相关脂肪性肝病（MASLD）的发病率正在上升。内脂素是一种源自肝脏的肽，参与葡萄糖和脂质稳态，在患有代谢紊乱和心血管疾病（CVD）的成年人中其水平降低。血清内脂素在年轻男性中也可能高于女性。先前的一项研究报告称，患有MASLD的青少年血清内脂素水平降低，但未报告肝脏组织学与CVD危险因素之间的关系。我们检验了以下假设：（1）与无MASLD的肥胖（Ob）或正常体重（NW）青少年相比，患有MASLD的青少年内脂素水平降低；（2）内脂素与血压（BP）、动脉僵硬度和肝脏组织病理学相关；（3）男孩的内脂素水平高于女孩。

方法

分别对47例MASLD患者以及27例Ob对照组和29例NW对照组参与者测量血清内脂素。

结果

与Ob组和NW组相比，MASLD组的内脂素水平并未降低，反而分别高出5%和20%（p>0.42）。内脂素浓度与动脉僵硬度或BP无关。在整个研究队列中，男孩的内脂素水平比女孩高20%（p=0.034）。这种差异在Ob组中很明显（p=0.018），但在NW组（p=0.537）或MASLD组（p=0.893）中不明显。仅在MASLD组中，内脂素与年龄呈正相关（r=0.46，p<0.001）。