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孟加拉国新出现的2.3.4.4b分支A(H5N1)高致病性禽流感病毒的重配

Reassortment of newly emergent clade 2.3.4.4b A(H5N1) highly pathogenic avian influenza A viruses in Bangladesh.

作者信息

Barman Subrata, Turner Jasmine C M, Hasan M Kamrul, Akhtar Sharmin, Jeevan Trushar, Franks John, Walker David, Mukherjee Nabanita, Seiler Patrick, Kercher Lisa, McKenzie Pamela, Webster Robert G, Feeroz Mohammed M, Webby Richard J

机构信息

Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.

Department of Zoology, Jahangirnagar University, Savar, Dhaka, Bangladesh.

出版信息

Emerg Microbes Infect. 2025 Dec;14(1):2432351. doi: 10.1080/22221751.2024.2432351. Epub 2024 Dec 9.

DOI:10.1080/22221751.2024.2432351
PMID:39584394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11632930/
Abstract

Avian influenza active surveillance was conducted in Bangladesh from January 2022 to November 2023 in live-poultry markets (LPMs) and Tanguar Haor wetlands. The predominant viruses circulating in LPMs were low pathogenic avian influenza (LPAI) A(H9N2) and clade 2.3.2.1a highly pathogenic avian influenza (HPAI) A(H5N1) viruses. Non-H9N2 LPAIs were found at Tanguar Haor and at a lower prevalence in LPMs. Starting from June 2023, we detected novel genotypes of clade 2.3.4.4b A(H5N1) viruses from ducks in LPMs. The HA, NA, and M genes of these viruses are related to those of 2020 European clade 2.3.4.4b H5N1 viruses such as A/Eurasian Wigeon/Netherlands/1/2020 (Netherlands/1). However, analyses of the other five gene segments' sequences identified three distinct genotypes (BD-G2, BD-G3, and BD-G4). BD-G2 viruses were closely related to the clade 2.3.4.4b H5N1 viruses that have been detected in Japan and nearby regions since November 2022. BD-G3 viruses were reassortants, with gene segments from other Eurasian LPAI viruses. BD-G4 viruses were similar to BD-G2 viruses, but their NS gene was accrued from contemporary Bangladeshi clade 2.3.2.1a A(H5N1) viruses. The ability of any of the clade 2.3.4.4b viruses to displace the long-entrenched 2.3.2.1a A(H5N1) viruses in Bangladesh is unknown.

摘要

2022年1月至2023年11月期间，在孟加拉国的活禽市场和坦瓜尔豪尔湿地开展了禽流感主动监测。活禽市场中传播的主要病毒是低致病性禽流感（LPAI）A（H9N2）和2.3.2.1a分支高致病性禽流感（HPAI）A（H5N1）病毒。在坦瓜尔豪尔发现了非H9N2低致病性禽流感病毒，在活禽市场中的流行率较低。从2023年6月开始，我们在活禽市场的鸭子中检测到了2.3.4.4b分支A（H5N1）病毒的新型基因型。这些病毒的血凝素（HA）、神经氨酸酶（NA）和基质（M）基因与2020年欧洲2.3.4.4b分支H5N1病毒（如A/欧亚野鸭/荷兰/1/2020（荷兰/1））的相关基因有关。然而，对其他五个基因片段序列的分析确定了三种不同的基因型（BD-G2、BD-G3和BD-G4）。BD-G2病毒与2022年11月以来在日本及附近地区检测到的2.3.4.4b分支H5N1病毒密切相关。BD-G3病毒是重组病毒，其基因片段来自其他欧亚低致病性禽流感病毒。BD-G4病毒与BD-G2病毒相似，但其非结构蛋白（NS）基因源自当代孟加拉国2.3.2.1a分支A（H5N1）病毒。目前尚不清楚2.3.4.4b分支的任何一种病毒是否有能力取代在孟加拉国长期存在的2.3.2.1a分支A（H5N1）病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/14c1fa1bef99/TEMI_A_2432351_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/1c9c148e2241/TEMI_A_2432351_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/425ebb420544/TEMI_A_2432351_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/d8834ba4d8f9/TEMI_A_2432351_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/14c1fa1bef99/TEMI_A_2432351_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/1c9c148e2241/TEMI_A_2432351_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/425ebb420544/TEMI_A_2432351_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/d8834ba4d8f9/TEMI_A_2432351_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c641/11632930/14c1fa1bef99/TEMI_A_2432351_F0004_OC.jpg

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