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韩国 2022-2023 年野鸟中高致病性禽流感 A(H5N1) 病毒 2.3.4.4b 分支的进化和传播。

Evolution and Spread of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, South Korea, 2022-2023.

出版信息

Emerg Infect Dis. 2024 Feb;30(2):299-309. doi: 10.3201/eid3002.231274. Epub 2024 Jan 12.

DOI:10.3201/eid3002.231274
PMID:38215495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10826760/
Abstract

During October 2022-March 2023, highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b virus caused outbreaks in South Korea, including 174 cases in wild birds. To understand the origin and role of wild birds in the evolution and spread of HPAI viruses, we sequenced 113 HPAI isolates from wild birds and performed phylogenetic analysis. We identified 16 different genotypes, indicating extensive genetic reassortment with viruses in wild birds. Phylodynamic analysis showed that the viruses were most likely introduced to the southern Gyeonggi-do/northern Chungcheongnam-do area through whooper swans (Cygnus cygnus) and spread southward. Cross-species transmission occurred between various wild bird species, including waterfowl and raptors, resulting in the persistence of HPAI in wild bird populations and further geographic spread as these birds migrated throughout South Korea. Enhanced genomic surveillance was an integral part of the HPAI outbreak response, aiding in timely understanding of the origin, evolution, and spread of the virus.

摘要

2022 年 10 月至 2023 年 3 月期间，高致病性禽流感（HPAI）A(H5N1) 谱系 2.3.4.4b 病毒在韩国引发疫情，包括野鸟中的 174 例病例。为了了解野鸟在 HPAI 病毒的进化和传播中的起源和作用，我们对 113 株野鸟来源的 HPAI 分离株进行了测序，并进行了系统发育分析。我们鉴定出了 16 种不同的基因型，表明与野鸟中病毒的广泛基因重配。系统发育动力学分析表明，病毒很可能通过大天鹅（Cygnus cygnus）传入南部京畿道/北部忠清南道地区，并向南传播。各种野生鸟类（包括水禽和猛禽）之间发生了跨物种传播，导致 HPAI 在野生鸟类种群中持续存在，并随着这些鸟类在韩国各地迁徙而进一步在地理上扩散。增强的基因组监测是 HPAI 疫情应对的一个组成部分，有助于及时了解病毒的起源、进化和传播。

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