Robust Sodium Carboxymethyl Cellulose-Based Neuromorphic Device with High Biocompatibility Engineered through Molecular Polarization for the Emulation of Learning Behaviors in the Human Brain.

Sodium carboxymethyl cellulose (CMC-Na), derived from natural cellulose and frequently employed as a biocompatible coating, thus renders it an ideal component for the construction of highly biocompatible neuromorphic devices aimed at biomachine interfaces. Here, an array of Mo/CMC-Na/ITO neuromorphic devices is fabricated, with CMC-Na serving as the functional layer. The devices exhibit capabilities to emulate various synaptic learning rules and demonstrate high endurance performance among biomaterial-based electronics, achieving stability over 2 × 10 pulses. Then, simulations of human brain-inspired learning and forgetting paradigms are conducted, highlighting the versatility of the device array in mimicking learning processes. Applications in pattern recognition leverage "learning-forgetting" paradigms, showcasing the potential of the device in cognitive tasks. Electrical measurements elucidate the mechanism of molecular polarization rotation, which offers insights into the modulation of synaptic weights within biocompatible biomaterial-based devices. Furthermore, the biocompatible properties of the devices are evaluated using human embryonic kidney 293 cells, confirming their excellent biocompatibility. The biodegradability of the devices is assessed by using physical transient tests to evaluate their sustainability in biomedical applications. Such advances represent pivotal improvements in implantable bioinspired electronics and show potential in biomachine interface and cognitive computing applications.