Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Smith Building, Room 626D, 1 Jimmy Fund Way, Boston, MA, 02115, USA.
Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Building 2, Room C10, 6439 Garners Ferry Road, Columbia, SC, 29209, USA.
Curr Allergy Asthma Rep. 2024 Nov 25;25(1):5. doi: 10.1007/s11882-024-01183-5.
Clinical interest in non-IgE activation of mast cells has been growing since the description of the human MRGPRX2 receptor. Its participation in many allergic and inflammatory conditions such as non histaminergic itch, urticaria, asthma and drug hypersensitivity has been growing. We present here an updated review of its structure, expression and biology to help understand conditions and diseases attributed to its activation and/or overpexression and the search for agonists and antagonists of clinical utility.
The description of patients presenting anaphylaxis when exposed to one or multiple MRGPRX2 agonists such as general anesthetics, antibiotics, opiods and other agents has provided evidence of potential heterogeneity in humans. This review provides the most recent developments into the receptor structure, tissue expression and signaling pathways including the potential enhancement of IgE-mediated mast cell activation. New insight into its agonists and antagonists is described and future developments to adress its modulations.
自人类 MRGPRX2 受体被描述以来，人们对肥大细胞非 IgE 激活的临床兴趣日益浓厚。它参与了许多过敏和炎症性疾病，如非组胺性瘙痒、荨麻疹、哮喘和药物超敏反应。我们在此介绍了其结构、表达和生物学的最新综述，以帮助理解归因于其激活和/或过表达的疾病，并寻找具有临床应用价值的激动剂和拮抗剂。
描述了一些患者在接触一种或多种 MRGPRX2 激动剂（如全身麻醉剂、抗生素、阿片类药物和其他药物）时会出现过敏反应，这为人类的潜在异质性提供了证据。本综述提供了该受体结构、组织表达和信号通路的最新进展，包括 IgE 介导的肥大细胞激活的潜在增强。描述了对其激动剂和拮抗剂的新见解，并探讨了其调节的未来发展。
