文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

新型双环杂环化合物作为治疗炎症性疾病的MRGPRX2拮抗剂

Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases.

作者信息

Sabnis Ram W

机构信息

Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Atlanta, Georgia 30309, United States.

出版信息

ACS Med Chem Lett. 2025 Jun 2;16(6):980-981. doi: 10.1021/acsmedchemlett.5c00305. eCollection 2025 Jun 12.

DOI:10.1021/acsmedchemlett.5c00305
PMID:40529074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12169468/
Abstract

Provided herein are novel bicyclic heterocycles as MRGPRX2 antagonists, pharmaceutical compositions, use of such compounds in treating inflammatory diseases, and processes for preparing such compounds.

摘要

本文提供了作为MRGPRX2拮抗剂的新型双环杂环化合物、药物组合物、此类化合物在治疗炎性疾病中的用途以及制备此类化合物的方法。

相似文献

[1]
Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases.

ACS Med Chem Lett. 2025-6-2

[2]
Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases.

ACS Med Chem Lett. 2025-4-2

[3]
Novel Bicyclic Heterocyclic Compounds as CD73 Inhibitors for Treating Cancer.

ACS Med Chem Lett. 2024-12-4

[4]
Bicyclic Ureas as JAK2 Inhibitors for Treating Hematological Cancer.

ACS Med Chem Lett. 2024-10-29

[5]
Novel Bicyclic Amines as CDK2 Inhibitors for Treating Metastatic Breast Cancer or Metastatic Lung Cancer.

ACS Med Chem Lett. 2025-1-16

[6]
Novel Bicyclic DGK Inhibitors for Treating Metastatic Melanoma.

ACS Med Chem Lett. 2025-4-2

[7]
Novel Tryptamine Compounds as 5-HT2A Agonists for Treating Mood Disorders such as Depressive Disorders and Bipolar Disorders.

ACS Med Chem Lett. 2025-2-13

[8]
Novel Ergoline Compounds as 5-HT2A Agonists for Treating Mood Disorders Such as Depressive Disorders and Bipolar Disorders.

ACS Med Chem Lett. 2024-12-20

[9]
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders.

ACS Med Chem Lett. 2024-12-10

[10]
Novel Compounds as NLRP3 Inhibitors for Treating Cardiovascular Diseases.

ACS Med Chem Lett. 2024-7-11

本文引用的文献

[1]
Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases.

ACS Med Chem Lett. 2025-4-2

[2]
Mast Cells and Mas-related G Protein-coupled Receptor X2: Itching for Novel Pathophysiological Insights to Clinical Relevance.

Curr Allergy Asthma Rep. 2024-11-25

[3]
Mast cell modulation: A novel therapeutic strategy for abdominal pain in irritable bowel syndrome.

Cell Rep Med. 2024-10-15

[4]
The evolving role of mast cells in wound healing: insights from recent research and diverse models.

Immunol Cell Biol. 2024-11

[5]
The MRGPR family of receptors in immunity.

Immunity. 2024-1-9

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索