Chen Liji, Cheng Shaoyu, Zhang Beiping, Zhong Cailing
The Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Department of Gastroenterology, The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Autoimmun Rev. 2025 Jan 31;24(2):103708. doi: 10.1016/j.autrev.2024.103708. Epub 2024 Nov 23.
The number of elderly patients with inflammatory bowel disease (IBD) has increased dramatically over the past few decades. Understanding the global burden of IBD in the elderly can provide a valuable basis for formulating future healthcare policies. This study aimed to comprehensively assess the global burden of IBD in the elderly from 1990 to 2019.
We extracted prevalence, incidence, disability-adjusted life-years (DALYs), and mortality data of older adults (60-89 years old) with IBD from 2010 to 2019 from the Global Burden of Disease (GBD) Study 2019, and analyzed in subgroups according to region, country, Socio-demographic Index (SDI), age group, and gender. Additionally, Trends in the global burden of IBD in old age from 1990 to 2019 were analyzed by calculating the estimated annual percentage change (EAPC) in the age-standardized rates (ASDs).
From 1990 to 2019, the number of prevalent cases, incident cases, DALYs, and deaths of IBD in older adults increased significantly. Age-standardized rates of incidence, prevalence, DALYs, and mortality all trended downward. Americas, European regions, and high SDI countries had consistently high burdens. Middle SDI countries had the fastest growth in prevalence, incidence, and the fastest decline in DALYs, and mortality. The age-standardized rates of prevalence, incidence, and DALYs for IBD in the elderly were highest in the 60-64 age group, and age-standardized rates of mortality were highest in the 80-84 and 85-89 age groups. No gender differences were observed when stratified by gender.
IBD in older adults has become a global public health burden due to significant increases in the number of prevalent cases, incident cases, DALYs, and deaths. There are marked differences among regions, countries, and between different age groups. Public health practitioners should develop targeted policies to effectively reduce the disease burden of IBD in older adults.
在过去几十年中，老年炎症性肠病（IBD）患者数量急剧增加。了解老年人IBD的全球负担可为制定未来医疗保健政策提供有价值的依据。本研究旨在全面评估1990年至2019年全球老年人IBD的负担。
我们从《2019年全球疾病负担（GBD）研究》中提取了2010年至2019年60 - 89岁IBD老年人的患病率、发病率、伤残调整生命年（DALYs）和死亡率数据，并根据地区、国家、社会人口指数（SDI）、年龄组和性别进行亚组分析。此外，通过计算年龄标准化率（ASDs）的估计年百分比变化（EAPC），分析了1990年至2019年老年IBD全球负担的趋势。
1990年至2019年，老年人IBD的患病率、发病率、DALYs和死亡人数显著增加。年龄标准化发病率、患病率、DALYs和死亡率均呈下降趋势。美洲、欧洲地区和高SDI国家的负担一直很高。中等SDI国家的患病率、发病率增长最快，DALYs和死亡率下降最快。老年人IBD的年龄标准化患病率、发病率和DALYs在60 - 64岁年龄组最高，年龄标准化死亡率在80 - 84岁和85 - 89岁年龄组最高。按性别分层时未观察到性别差异。
由于患病率、发病率、DALYs和死亡人数显著增加，老年人IBD已成为全球公共卫生负担。不同地区、国家和不同年龄组之间存在明显差异。公共卫生从业者应制定针对性政策，有效降低老年人IBD的疾病负担。
