Romero Leire Rodríguez, Acharya Neha, Nabás Jaime Fabregat, Marín Ignacio, Andero Raül
Institut de Neurociències, Universistat Autònoma de Barcelona, Barcelona, Spain.
Departament de Psicobiologia i Metodología de les Ciències de la Salut, Universistat Autònoma de Barcelona, Barcelona, Spain.
Curr Top Behav Neurosci. 2024 Nov 26. doi: 10.1007/7854_2024_543.
Neural circuitry involved in anxiety and fear-related disorders exhibits strong sexual modulation. A limited number of studies integrating female and male data have revealed differences in neural networks, and distinct interconnectivity between these brain areas. Despite the efforts to incorporate female or mixed-sex data, there is compelling evidence that sex, as a biological variable, significantly influences fear processing. This chapter presents primary findings on sex differences in fear circuitry. It is imperative to consider this factor to ensure scientific research's integrity and understand how fear is processed in the central nervous system.
参与焦虑和恐惧相关障碍的神经回路表现出强烈的性别差异调节。少数整合了女性和男性数据的研究揭示了神经网络的差异，以及这些脑区之间不同的相互连接性。尽管人们努力纳入女性或混合性别的数据，但有确凿证据表明，性别作为一个生物学变量，会显著影响恐惧处理。本章介绍了恐惧神经回路中性别差异的主要研究结果。考虑这一因素对于确保科学研究的完整性以及理解中枢神经系统中恐惧是如何处理的至关重要。
