Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guangzhou Institute of Respiratory Health Guangzhou, Guangzhou, China.
Cell Death Dis. 2024 Nov 26;15(11):859. doi: 10.1038/s41419-024-07244-x.
Regulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms. However, intense evidences suggest that lipid peroxidation can be the common feature that initiates and propagates the cell death. Excessive lipid peroxidation alters the property of membrane and further damage the proteins and nucleic acids, which is implicated in various human pathologies. Here, we firstly review the classical chain process of lipid peroxidation, and further clarify the current understanding of the myriad roles and molecular mechanisms of lipid peroxidation in various RCD types. We also discuss how lipid peroxidation involves in diseases and how such intimate association between lipid peroxidation-driven cell death and diseases can be leveraged to develop rational therapeutic strategies.
调控性细胞死亡（RCD）是指可以通过各种生物大分子来调控的细胞死亡形式。每种细胞死亡方式都有其独特的形态变化和分子机制。然而，大量证据表明，脂质过氧化可以作为启动和传播细胞死亡的共同特征。过量的脂质过氧化会改变膜的性质，并进一步破坏蛋白质和核酸，这与各种人类疾病有关。在这里，我们首先回顾了脂质过氧化的经典链式过程，并进一步阐明了目前对脂质过氧化在各种 RCD 类型中的多种作用和分子机制的理解。我们还讨论了脂质过氧化如何涉及疾病，以及这种脂质过氧化驱动的细胞死亡与疾病之间的密切关系如何被用来开发合理的治疗策略。
