多发性硬化症中动作性震颤对异烟肼的反应及其用偏振光测角术进行的评估。
The response to isoniazid of action tremor in multiple sclerosis and its assessment using polarised light goniometry.
作者信息
Francis D A, Grundy D, Heron J R
出版信息
J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):87-9. doi: 10.1136/jnnp.49.1.87.
Abstract
Isonicotinic acid hydrazide (isoniazid) was evaluated in five patients as a treatment for the control of severe cerebellar action tremor occurring in multiple sclerosis. Oral doses of isoniazid BPC were increased every 2 weeks from 300 mg to 1200 mg daily over an 8 week period. Four patients reported considerable symptomatic benefit at doses ranging from 600 mg to 900 mg daily. Polarised light goniometry demonstrated a two to three-fold reduction of tremor in these patients when standard methods of clinical assessment showed only marginal improvement.
摘要
对五名患者使用异烟肼评估其对多发性硬化症中出现的严重小脑性动作震颤的控制效果。在8周的时间内，口服英国药典标准的异烟肼剂量每2周从每日300毫克增加至1200毫克。四名患者报告称，在每日剂量为600毫克至900毫克时，症状有显著改善。偏振光测角法显示，这些患者的震颤减轻了两到三倍，而此时临床评估的标准方法仅显示有轻微改善。
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