各种神经和精神疾病中的脑脊液γ-氨基丁酸水平。
Cerebrospinal fluid GABA levels in various neurological and psychiatric diseases.
作者信息
Kuroda H, Ogawa N, Yamawaki Y, Nukina I, Ofuji T, Yamamoto M, Otsuki S
出版信息
J Neurol Neurosurg Psychiatry. 1982 Mar;45(3):257-60. doi: 10.1136/jnnp.45.3.257.
Abstract
Cerebrospinal fluid gamma-aminobutyric acid (CSF-GABA) was analysed by radioreceptor assay in 16 normal controls and 84 patients with various neurological and psychiatric diseases. In patients with spinocerebellar degeneration, neuro-Behçet's syndrome and Parkinson's disease, CSF-GABA levels were decreased. On the other hand, increased CSF-GABA levels were detected in patients with meningitis.
摘要
采用放射受体分析法对16名正常对照者和84名患有各种神经和精神疾病的患者的脑脊液γ-氨基丁酸（CSF-GABA）进行了分析。在脊髓小脑变性、神经贝赫切特综合征和帕金森病患者中，CSF-GABA水平降低。另一方面，在脑膜炎患者中检测到CSF-GABA水平升高。
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本文引用的文献
1
gamma-Aminobutyric acid in brain: its formation from glutamic acid.大脑中的γ-氨基丁酸：其由谷氨酸形成的过程。
J Biol Chem. 1950 Nov;187(1):55-63.
2
Cholinergic and non-cholinergic nerve endings in rat brain. I. Isolation and subcellular distribution of acetylcholine and acetylcholinesterase.大鼠脑中的胆碱能和非胆碱能神经末梢。I. 乙酰胆碱和乙酰胆碱酯酶的分离及亚细胞分布
J Neurochem. 1962 Jan-Feb;9:23-35. doi: 10.1111/j.1471-4159.1962.tb07489.x.
3
Levels of gamma-aminobutyric acid in cerebrospinal fluid in various neurologic disorders.各种神经系统疾病患者脑脊液中γ-氨基丁酸的水平
Arch Neurol. 1980 Jun;37(6):352-5. doi: 10.1001/archneur.1980.00500550054006.
4
Regional distribution of gamma-aminobutyric acid (GABA) in brain of the rhesus monkey.恒河猴大脑中γ-氨基丁酸（GABA）的区域分布。
J Neurochem. 1968 Mar;15(3):209-13. doi: 10.1111/j.1471-4159.1968.tb06198.x.
5
Biochemical-physiological correlations in studies of the gamma-aminobutyric acid system.γ-氨基丁酸系统研究中的生化-生理相关性
Brain Res. 1968 Apr;8(1):1-35. doi: 10.1016/0006-8993(68)90170-4.
6
L-glutamic acid decarboxylase in Parkinson's disease: effect of L-dopa therapy.帕金森病中的L-谷氨酸脱羧酶：左旋多巴治疗的效果
Nature. 1973 Jun 29;243(5409):521-3. doi: 10.1038/243521a0.
7
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J Anat. 1973 Apr;114(Pt 3):365-78.
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10
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