Department of Transfusion, Affiliated Hospital of North Sichuan Medical college, Nanchong, Sichuan, P.R. China.
Department of Cardiovascular Surgery, Affiliated Hospital of North Sichuan Medical college, Nanchong, Sichuan, P.R. China.
J Transl Med. 2024 Nov 25;22(1):1057. doi: 10.1186/s12967-024-05740-4.
Iron overload is a pathological condition characterized by the abnormal accumulation of iron within the body, which may result from excessive iron intake, disorders of iron metabolism, or specific disease states. This condition can lead to significant health complications and may pose life-threatening risks. The excessive accumulation of iron can induce cellular stress, adversely affecting the structure and function of mitochondria, thereby compromising overall organ function. Given the critical role of mitochondria in cellular metabolism and homeostasis, it is imperative to investigate how mitochondrial dysfunction induced by iron overload contributes to disease progression, as well as to explore mitochondrial-related pathways as potential therapeutic targets for various iron overload disorders. This review examines the mechanisms by which mitochondria are implicated in iron overload-induced damage, including increased oxidative stress, mitochondrial DNA damage, and disruptions in energy metabolism. Additionally, it addresses the relationship between these processes and various forms of programmed cell death, as well as alterations in mitochondrial dynamics. Furthermore, the review discusses strategies aimed at alleviating and mitigating the complications associated with iron overload in patients by targeting mitochondrial pathways.
铁过载是一种病理状态，其特征是体内铁的异常积累，这可能是由于铁摄入过多、铁代谢紊乱或特定疾病状态引起的。这种情况会导致严重的健康并发症，并可能构成生命威胁。铁的过度积累会引起细胞应激，对线粒体的结构和功能产生不利影响，从而损害整体器官功能。鉴于线粒体在细胞代谢和内稳态中的关键作用，研究铁过载引起的线粒体功能障碍如何导致疾病进展至关重要，探索线粒体相关途径作为各种铁过载疾病的潜在治疗靶点也至关重要。本综述探讨了线粒体参与铁过载诱导损伤的机制，包括增加的氧化应激、线粒体 DNA 损伤和能量代谢紊乱。此外，还讨论了这些过程与各种形式的程序性细胞死亡以及线粒体动力学改变之间的关系。此外，该综述还讨论了通过靶向线粒体途径缓解和减轻患者铁过载相关并发症的策略。
