Neally Sam J, Widen Elizabeth M, Hoyo Cathrine, Martin Chantel L
Department of Epidemiology, UNC Gillings School of Public Health, Chapel Hill, North Carolina, USA.
Department of Nutritional Sciences, School of Human Ecology, UT Austin, Austin, Texas, USA.
Pediatr Obes. 2025 Feb;20(2):e13188. doi: 10.1111/ijpo.13188. Epub 2024 Nov 25.
This study aimed to examine associations between prenatal neighbourhood socioeconomic deprivation (NSD) with early offspring weight status and to assess potential modification by race and ethnicity.
We used data from the Newborn Epigenetics STudy (NEST) cohort. Gestational NSD was assessed as neighbourhood deprivation index (NDI) tertiles. Offspring height and weight were assessed at 6 months (N = 1023), 1 year (N = 1268), 2 years (N = 1033) and 3 years (N = 1038). Multilevel logistic regression models estimated odds ratios (OR) and 95% confidence intervals (CI) for the relationship of NDI with overweight or obesity and rapid infant weight gain, adjusting for gestational parent age, race/ethnicity, marital status and educational attainment. Models were estimated in the total sample and also stratified by race and ethnicity.
Children exposed to NDI in the highest (compared to the lowest) tertile had increased odds of having overweight/obesity at 1 year (OR = 1.53, 95%CI = 1.09-2.15). In stratified models, children of NH Black gestational parents residing in the highest tertile of NDI (compared to the lowest) had increased odds of having overweight/obesity at 1 year (OR = 1.67, 95%CI = 1.00-2.77).
This findings suggest that higher gestational exposure to NSD may play a role in early childhood weight status, which has important implications for later development and health.
本研究旨在探讨产前邻里社会经济剥夺（NSD）与子代早期体重状况之间的关联，并评估种族和民族的潜在影响。
我们使用了新生儿表观遗传学研究（NEST）队列的数据。孕期NSD被评估为邻里剥夺指数（NDI）三分位数。在6个月（N = 1023）、1岁（N = 1268）、2岁（N = 1033）和3岁（N = 1038）时对子代的身高和体重进行评估。多水平逻辑回归模型估计了NDI与超重或肥胖以及婴儿体重快速增加之间关系的优势比（OR）和95%置信区间（CI），并对孕期父母年龄、种族/民族、婚姻状况和教育程度进行了调整。模型在总样本中进行估计，并按种族和民族进行分层。
暴露于最高（与最低相比）三分位数NDI的儿童在1岁时超重/肥胖的几率增加（OR = 1.53，95%CI = 1.09 - 2.15）。在分层模型中，孕期父母为非西班牙裔黑人且居住在NDI最高三分位数（与最低相比）的儿童在1岁时超重/肥胖的几率增加（OR = 1.67，95%CI = 1.00 - 2.77）。
这些发现表明，孕期较高的NSD暴露可能在儿童早期体重状况中起作用，这对后期发育和健康具有重要意义。
