Graphene-Enhanced Refreshable Metasurface Expands Analytes of THz Label-Free Sensing and Achieves Picogram Limit of Detection.

THz sensing offers unique advantages including strong penetrability, low photon energy, and specific recognition of biomolecules and chemicals. However, current label-free THz sensors all operate below 1 THz, severely limiting applications as many drugs and chemicals vibrate at higher THz frequencies. Moreover, the THz detection of analytes at picogram levels is challenging. Here, a modern graphene-enhanced THz metasurface label-free sensor is presented. Its tunable resonance from ∼1.8 to 2.6 THz matches the fingerprint resonant frequencies of various analytes not currently detectable by label-free THz sensing. Quantitative detection of trace 1,3-DNB (absorbing at ∼2.52 THz) is first achieved with a maximum reflectance sensitivity of ∼10% pmol and a detection limit of 42 pg. The sensor can also be refreshed, minimizing cost and being more environmentally friendly. Our strategy expands application scenarios of label-free THz sensing, enhancing its potential in fields such as the pharmaceutical industry, environmental monitoring, and security.