School of Medicine, Kunming University of Science and Technology, Kunming, China.
Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, China.
Front Immunol. 2024 Nov 11;15:1478374. doi: 10.3389/fimmu.2024.1478374. eCollection 2024.
Inflammatory bowel disease (IBD) is a chronic, systemic gastrointestinal disorder characterized by episodic inflammation that requires life-long management. Although the etiology of IBD is not fully understood, it is hypothesized to involve a multifaceted interplay among genetic susceptibility, the host immune response, and environmental factors. Previous studies have largely concluded that IBD is associated with this complex interplay; however, more recent evidence underscores the significant role of dietary habits as risk factors for the development of IBD. In this review, we review the molecular mechanisms of high-sugar and high-fat diets in the progression of IBD and specifically address the impacts of these diets on the gut microbiome, immune system regulation, and integrity of the intestinal barrier, thereby highlighting their roles in the pathogenesis and exacerbation of IBD.
炎症性肠病（IBD）是一种慢性、全身性胃肠道疾病，其特征为反复发作的炎症，需要终身管理。尽管 IBD 的病因尚未完全阐明，但据推测，它涉及遗传易感性、宿主免疫反应和环境因素之间的多方面相互作用。先前的研究大多得出结论，认为 IBD 与这种复杂的相互作用有关；然而，最近的证据强调了饮食习惯作为 IBD 发展的危险因素的重要作用。在这篇综述中，我们回顾了高糖和高脂肪饮食在 IBD 进展中的分子机制，并特别探讨了这些饮食对肠道微生物组、免疫系统调节和肠道屏障完整性的影响，从而强调了它们在 IBD 的发病机制和恶化中的作用。
