Yang Tingting, Beach Kylie E, Zhu Chendi, Gan Mingyu, Wang Wenli, Zhou Hongjuan, Peng Lijun, Wang Shanshan, Cai Long, Li Weimin, Davis Jordan B, Cicchetti Nico, Slechta E Susan, Barker Adam, Shakir Salika M, Carey Allison F, Liu Qingyun
Clinical Laboratory Experiment Center, Hangzhou Red Cross Hospital, Zhejiang, 310003, China.
Department of Pathology, University of Utah, Salt Lake City, Utah, 84112, USA.
J Infect Dis. 2024 Nov 26. doi: 10.1093/infdis/jiae580.
Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood. We analyzed published genomes of 5,617 clinical MAB isolates from 20 countries and searched for signals of ongoing evolution in 35 drug-resistance-associated genes. Of these, we found 14 genes were subject to positive selection and identified novel mutational sites under selection. Among these, the erm(41) V80I mutation arose exclusively in strains with erm(41) 28T and affected 50.5% (1750/3465) of subsp. abscessus isolates. The study provided evidence that MAB is evolving mutations in drug-resistance-associated genes, and further research is needed to understand the functional consequences of these mutations.
脓肿分枝杆菌（MAB）对许多抗生素具有内在抗性，但对获得性耐药性的演变了解甚少。我们分析了来自20个国家的5617株临床MAB分离株的已发表基因组，并在35个与耐药性相关的基因中寻找正在发生进化的信号。其中，我们发现14个基因受到正选择，并鉴定出了正在选择的新突变位点。其中，erm(41) V80I突变仅出现在带有erm(41) 28T的菌株中，并且影响了50.5%（1750/3465）的脓肿亚种分离株。该研究提供了证据表明MAB正在耐药性相关基因中发生突变，需要进一步研究以了解这些突变的功能后果。
