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Is LPAR5 agonist a new treatment for microvilli inclusion disease?LPAR5激动剂是微绒毛包涵体病的一种新疗法吗？
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Lysophosphatidic Acid Receptor 5 (LPAR5) Plays a Significance Role in Papillary Thyroid Cancer via Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.溶血磷脂酸受体 5（LPAR5）通过磷脂酰肌醇 3-激酶/蛋白激酶 B/雷帕霉素靶蛋白（mTOR）通路在甲状腺乳头状癌中发挥重要作用。
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LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.LPAR5 通过激活 class IA PI3K 催化亚基 p110β 促进甲状腺癌细胞增殖和迁移。
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Altered cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activation.由MYO5B缺陷诱导的细胞代谢途径改变和上皮细胞成熟可通过LPAR5激活部分逆转。
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Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer.LPAR5 基因在甲状腺乳头状癌及泛癌预后和免疫中的潜在作用
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Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA-Dependent Signaling.肠内干细胞和祖细胞的存活受 LPA 依赖信号的调节。
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本文引用的文献

1
Alterations in cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activation.由MYO5B缺陷诱导的细胞代谢途径和上皮细胞成熟的改变可通过LPAR5激活部分逆转。
Am J Physiol Gastrointest Liver Physiol. 2024 Dec 1;327(6):G877-G899. doi: 10.1152/ajpgi.00091.2024. Epub 2024 Oct 15.
2
Lysophosphatidic Acid Signaling in the Gastrointestinal System.溶血磷脂酸信号在胃肠道系统中的作用。
Cell Mol Gastroenterol Hepatol. 2024;18(6):101398. doi: 10.1016/j.jcmgh.2024.101398. Epub 2024 Sep 2.
3
Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular Level.MYO5B 功能改变导致微绒毛包涵体病：在细胞水平进行干预的机会。
Cell Mol Gastroenterol Hepatol. 2022;14(3):553-565. doi: 10.1016/j.jcmgh.2022.04.015. Epub 2022 Jun 1.
4
Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA-Dependent Signaling.肠内干细胞和祖细胞的存活受 LPA 依赖信号的调节。
Cell Mol Gastroenterol Hepatol. 2022;14(1):129-150. doi: 10.1016/j.jcmgh.2022.03.012. Epub 2022 Apr 4.
5
Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance.细胞分化因Wnt/Notch失衡导致的MYO5B缺失而受到破坏。
JCI Insight. 2021 Aug 23;6(16):e150416. doi: 10.1172/jci.insight.150416.
6
Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.溶血磷脂酸受体 5 对肠道上皮通透性的控制作用。
Cell Mol Gastroenterol Hepatol. 2021;12(3):1073-1092. doi: 10.1016/j.jcmgh.2021.05.003. Epub 2021 May 8.
7
Lysophosphatidic Acid Increases Maturation of Brush Borders and SGLT1 Activity in MYO5B-deficient Mice, a Model of Microvillus Inclusion Disease.溶血磷脂酸增加 MYO5B 缺陷小鼠刷状缘的成熟和 SGLT1 活性，该小鼠模型为微绒毛包涵物病。
Gastroenterology. 2020 Oct;159(4):1390-1405.e20. doi: 10.1053/j.gastro.2020.06.008. Epub 2020 Jun 12.
8
Loss of MYO5B Leads to Reductions in Na Absorption With Maintenance of CFTR-Dependent Cl Secretion in Enterocytes.肌球蛋白 VB 缺失导致肠细胞中钠吸收减少，而 CFTR 依赖的氯离子分泌得以维持。
Gastroenterology. 2018 Dec;155(6):1883-1897.e10. doi: 10.1053/j.gastro.2018.08.025. Epub 2018 Aug 23.
9
Expression of lysophosphatidic acid receptor 5 is necessary for the regulation of intestinal Na/H exchanger 3 by lysophosphatidic acid in vivo.体内溶血磷脂酸通过激活溶血磷脂酸受体 5 调节肠道 Na/H 交换蛋白 3 的表达。
Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G433-G442. doi: 10.1152/ajpgi.00130.2018. Epub 2018 May 24.
10
Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.不同的磷酯酶 C-β同工酶介导溶血磷脂酸受体 1 对肠道上皮细胞稳态和伤口闭合的影响。
Mol Cell Biol. 2013 May;33(10):2016-28. doi: 10.1128/MCB.00038-13. Epub 2013 Mar 11.

Is LPAR5 agonist a new treatment for microvilli inclusion disease?

作者信息

Yun C Chris

机构信息

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.

Gastroenterology Research, Atlanta Veterans Administration Medical Center, Decatur, Georgia, United States.

出版信息

Am J Physiol Gastrointest Liver Physiol. 2025 Jan 1;328(1):G49-G50. doi: 10.1152/ajpgi.00355.2024. Epub 2024 Nov 26.

DOI:10.1152/ajpgi.00355.2024
PMID:39589437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12165318/
Abstract
摘要