Xiangya Nursing School, Central South University, Changsha, China.
School of Nursing, Hunan Traditional Chinese Medical College, Zhuzhou, China.
Front Endocrinol (Lausanne). 2023 Feb 16;14:1081096. doi: 10.3389/fendo.2023.1081096. eCollection 2023.
This systematic review and meta-analysis evaluates the overall effects of lifestyle interventions upon hepatic fat content and metabolism-related indicators among adults with metabolic associated fatty liver disease.
It was registered under PROSPERO (CRD42021251527). We searched PubMed, EMBASE, MEDLINE, Cochrane, CINAHL, Scopus, CNKI, Wan-fang, VIP, and CBM from the inception of each database to May 2021 for RCT studies of lifestyle interventions on hepatic fat content and metabolism-related indicators. We used Review Manager 5.3 for meta-analysis and used text and detailed tabular summaries when heterogeneity existed.
Thirty-four RCT studies with 2652 participants were included. All participants were obesity, 8% of whom also had diabetes, and none was lean or normal weight. Through subgroup analysis, we found low carbohydrate diet, aerobic training and resistance training significantly improved the level of HFC, TG, HDL, HbA1c, and HOMA-IR. Moreover, low carbohydrate diet is more effective in improving HFC than low fat diet and resistance training is better than aerobic training in reduction in HFC and TG (SMD, -0.25, 95% CI, -0.45 to -0.06; SMD, 0.24, 95% CI, 0.03 to 0.44, respectively).
Overall, this is the first review that systematically synthesizes studies focused on the effects of various lifestyle on adults with MAFLD. The data generated in this systematic review were more applicable to obesity MAFLD rather than lean or normal weight MAFLD.
https://www.crd.york.ac.uk/prospero/, identifier (CRD42021251527).
本系统评价和荟萃分析评估了生活方式干预对代谢相关脂肪性肝病成人肝脂肪含量和代谢相关指标的总体影响。
该研究已在 PROSPERO（CRD42021251527）上注册。我们检索了 PubMed、EMBASE、MEDLINE、Cochrane、CINAHL、Scopus、CNKI、万方、维普和 CBM 数据库，从每个数据库的创建时间到 2021 年 5 月，以获取关于生活方式干预对肝脂肪含量和代谢相关指标影响的随机对照试验研究。我们使用 Review Manager 5.3 进行荟萃分析，并在存在异质性时使用文本和详细的表格摘要。
纳入了 34 项 RCT 研究，共 2652 名参与者。所有参与者均为肥胖，其中 8%患有糖尿病，无消瘦或正常体重者。通过亚组分析，我们发现低碳水化合物饮食、有氧运动和抗阻运动可显著改善 HFC、TG、HDL、HbA1c 和 HOMA-IR 水平。此外，低碳水化合物饮食在改善 HFC 方面比低脂肪饮食更有效，而抗阻运动在降低 HFC 和 TG 方面比有氧运动更有效（SMD，-0.25，95%CI，-0.45 至-0.06；SMD，0.24，95%CI，0.03 至 0.44）。
总体而言，这是第一项系统综述，综合了各种生活方式对 MAFLD 成人影响的研究。本系统评价中生成的数据更适用于肥胖 MAFLD，而不适用于消瘦或正常体重 MAFLD。
