Zenick H, Hope E, Smith M K
J Toxicol Environ Health. 1986;17(4):457-72. doi: 10.1080/15287398609530840.
The present study was designed to evaluate the influence of acrylamide (ACR) on male and female reproductive function. Male rats received ACR in drinking water (50, 100, or 200 ppm) for up to 10 wk. Copulatory behavior, semen, and (for controls and 100 ppm only) fertility and fetal outcomes were evaluated. Females received ACR (25, 50, 100 ppm) for 2 wk prior to initiation of breeding and then throughout gestation and lactation. Hindlimb splaying was apparent in the 200-ppm males by wk 4; less severe splaying appeared in the 100-ppm group at wk 8. Disruptions in copulatory behavior preceded the appearance of this ataxia. These disruptions in mating performance interfered with ejaculatory processes and subsequent transport of sperm, since semen was found in the uterus of only 1 of the 15 females mated with the 100-ppm males at wk 9. Moreover, only 33% of the females mated (wk 10) to the 100-ppm males were pregnant. Postimplantation loss was also significantly increased in this group. Hindlimb splaying appeared in the females receiving 100 ppm ACR during wk 1-2 of pregnancy. Body weight and fluid intake were also depressed. Dams in the 50-ppm group showed depression in these parameters during the last 2 wk of lactation. ACR did not significantly affect mating performance of the females, pregnancy rates, litter size, or survival. However, ACR did significantly depress pup body weight at birth (100-ppm group) and weight gain during lactation through post-weaning, d 42 (50- and 100-ppm groups). Vaginal patency was delayed in the 100-ppm group only.
本研究旨在评估丙烯酰胺（ACR）对雄性和雌性生殖功能的影响。雄性大鼠饮用含ACR（50、100或200 ppm）的水长达10周。评估了交配行为、精液以及（仅针对对照组和100 ppm组）生育力和胎儿结局。雌性大鼠在开始繁殖前2周接受ACR（25、50、100 ppm）处理，然后在整个妊娠期和哺乳期持续接受处理。到第4周时，200 ppm组的雄性大鼠出现明显的后肢外展；第8周时，100 ppm组出现较轻程度的后肢外展。在这种共济失调出现之前，交配行为就已受到干扰。这些交配性能的干扰影响了射精过程及随后精子的运输，因为在第9周时，与100 ppm组雄性大鼠交配的15只雌性大鼠中，只有1只的子宫内发现了精液。此外，在第10周与100 ppm组雄性大鼠交配的雌性大鼠中，只有33%怀孕。该组着床后丢失也显著增加。在妊娠第1 - 2周接受100 ppm ACR的雌性大鼠出现后肢外展。体重和液体摄入量也降低。50 ppm组的母鼠在哺乳期的最后2周这些参数出现下降。ACR对雌性大鼠的交配性能、妊娠率、窝仔数或存活率没有显著影响。然而ACR确实显著降低了出生时幼崽的体重（100 ppm组）以及哺乳期至断奶后第42天的体重增加（50和100 ppm组）。仅100 ppm组的阴道开放延迟。
