López Cancino Sury Antonio, Eligio García Leticia, Crisóstomo Vázquez María Del Pilar, Soria Guerrero Mariana, Jiménez Cardoso Enedina, Meneses Mayo Marcos, Islas Andrade Sergio Agustín
Head of Health Research Office, IMSS BIENESTAR State Coordination Chiapas, Health Services of the Mexican Institute of Social Security for Welfare (IMSS-BIENESTAR), 16 South West 333, Tuxtla Gutiérrez 29067, Mexico.
Parasitology Research Laboratory, Children Hospital of México "Federico Gómez", Dr. Márquez 162, Col Doctores, Cuauhtémoc, Mexico City 06720, Mexico.
Trop Med Infect Dis. 2024 Nov 1;9(11):261. doi: 10.3390/tropicalmed9110261.
The Mexican state of Chiapas is considered epidemiologically significant for Chagas disease due to the coexistence of infected reservoirs and vectors, including migratory populations from Central and South America. However, there is a lack of monitoring programs for the timely detection of this disease. The objective of this study was to elucidate the prevalence of infection in pregnant women and the risk of vertical transmission in newborns at two hospitals located in the Metropolitan Region of Tuxtla Gutierrez, the capital of Chiapas State Mexico. A cross-sectional study was carried out with 193 pregnant women with gestational ages between 32 and 40 weeks, who underwent immunological testing to diagnose Chagas disease. Conventional PCR testing on cord blood revealed the presence of in newborns. The prevalence of infection in pregnant women was 32.12% (95% confidence interval (CI): 0.25, 0.38). The 62 pregnant women who tested positive for Chagas disease gave birth to 63 children, and in 5 newborns (8% (5/62), 95% confidence interval (CI): 0.02, 0.19), PCR tests on umbilical cord blood were positive for . In conclusion, the dataset showed a high prevalence of Chagas disease in the sample of pregnant women studied and a maternal-fetal transmission rate of 8%.
由于受感染的宿主和病媒（包括来自中美洲和南美洲的流动人口）共存，墨西哥恰帕斯州在流行病学上被认为是查加斯病的重要地区。然而，缺乏用于及时发现这种疾病的监测项目。本研究的目的是阐明墨西哥恰帕斯州首府图斯特拉古铁雷斯大都会区两家医院中孕妇的感染率以及新生儿垂直传播的风险。对193名孕周在32至40周之间的孕妇进行了横断面研究，这些孕妇接受了免疫检测以诊断查加斯病。对脐带血进行的常规聚合酶链反应（PCR）检测显示新生儿中存在[病原体名称未给出]。孕妇的感染率为32.12%（95%置信区间（CI）：0.25，0.38）。62名查加斯病检测呈阳性的孕妇生下了63名儿童，其中5名新生儿（8%（5/62），95%置信区间（CI）：0.02，0.19）的脐带血PCR检测呈[病原体名称未给出]阳性。总之，数据集显示在所研究的孕妇样本中查加斯病的患病率较高，母婴传播率为8%。
