对生活在墨西哥两个恰加斯病流行地区的母亲和新生儿进行克氏锥虫感染的血清学和寄生虫学筛查。
Serological and parasitological screening of Trypanosoma cruzi infection in mothers and newborns living in two Chagasic areas of Mexico.
作者信息
Olivera Mar Amonario, Guillén Ortega Fernando, Cruz Vidal Salatiel, Hernández-Becerril Nidia, Pérez Galdamez Enrique, Córdova Concepción Guzmán, Reyes Pedro A, Monteón Victor M
机构信息
Instituto Nacional Cardiología I. Chávez, México, DF, México.
出版信息
Arch Med Res. 2006 Aug;37(6):774-7. doi: 10.1016/j.arcmed.2006.02.006.
BACKGROUND
Maternal-fetal transmission of Trypanosoma cruzi generally occurs in 2-12% of pregnant infected mothers. This transmission form has been poorly studied in Mexico where only one case of congenital infection published in 1998 has been reported.
METHODS
We screened 145 mothers and their delivered babies in two hospitals of endemic regions in Mexico (states of Chiapas and Veracruz) searching for anti-T. cruzi antibodies and circulating parasites by hemoculture and PCR.
RESULTS
In Poza Rica, Veracruz, 3/85 (3.5%) mothers were seropositive for T. cruzi infection and in Palenque, Chiapas, 3/60 (5%) cases. In total 6/145 (4.1%) were seropositive subjects. Although cord blood samples of delivered babies from seropositive mothers have IgG anti-T. cruzi antibodies, none presented PCR and positive hemoculture.
CONCLUSIONS
Although a high relative seroprevalence of T. cruzi infection in pregnant women was detected, no case of vertical transmission was recognized. Undoubtedly, further studies of large samples are necessary to evaluate maternal transmission risk in Mexico.
背景
克氏锥虫的母婴传播通常发生在2%至12%的受感染孕妇中。在墨西哥，这种传播形式的研究较少，该国仅报告过1998年发表的1例先天性感染病例。
方法
我们在墨西哥（恰帕斯州和韦拉克鲁斯州）流行地区的两家医院对145名母亲及其分娩的婴儿进行了筛查，通过血培养和聚合酶链反应寻找抗克氏锥虫抗体和循环寄生虫。
结果
在韦拉克鲁斯州的波萨里卡，85名母亲中有3名（3.5%）克氏锥虫感染血清学呈阳性，在恰帕斯州的帕伦克，60名母亲中有3名（约5%）呈阳性。总计145名中有6名（4.1%）血清学呈阳性。尽管血清学呈阳性母亲所分娩婴儿的脐带血样本中有抗克氏锥虫IgG抗体，但无一例聚合酶链反应呈阳性或血培养呈阳性。
结论
尽管检测到孕妇中克氏锥虫感染的相对血清阳性率较高，但未发现垂直传播病例。毫无疑问，有必要对大量样本进行进一步研究，以评估墨西哥的母婴传播风险。
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