Ozaki H S, Murakami T H, Toyoshima T, Shimada M
J Neurosci Res. 1986;15(2):241-52. doi: 10.1002/jnr.490150213.
This research examined the effects of kainic-acid (KA)-induced hippocampal lesions on the acquisition of a jump-box avoidance task in mice. When the hippocampal lesion was unilateral, mice with lesions in the lateral portion of the CA1 region showed deficits in acquisition while those with lesions in the CA3 region and/or the medial portion of the CA1 region did not. When the hippocampal lesion was bilateral, on the other hand, mice with lesions in the CA3 region and/or the lateral portion of the CA1 region were deficient in acquisition while those with lesions in the medial portion of the CA1 region were not. Among the mice with various KA-induced hippocampal lesions avoidance responses were not correlated with the level of open field activity, indicating that acquisition differences observed are not dependent upon, nor secondary to, levels of spontaneous activity. These results strongly suggest that there exist regional differences in the involvement of hippocampal pyramidal cell layers in acquisition of the jump-box avoidance task: both the CA3 region and the lateral portion of the CA1 region are involved in acquisition, while the medial portion of the CA1 region is not.
本研究考察了海藻酸（KA）诱导的海马损伤对小鼠跳箱回避任务习得的影响。当海马损伤为单侧时，CA1区外侧部分有损伤的小鼠在习得方面表现出缺陷，而CA3区和/或CA1区内测部分有损伤的小鼠则没有。另一方面，当海马损伤为双侧时，CA3区和/或CA1区外侧部分有损伤的小鼠在习得方面存在缺陷，而CA1区内测部分有损伤的小鼠则没有。在各种KA诱导的海马损伤的小鼠中，回避反应与旷场活动水平无关，这表明观察到的习得差异并不依赖于自发活动水平，也不是自发活动水平的继发结果。这些结果有力地表明，海马锥体细胞层在跳箱回避任务习得中的参与存在区域差异：CA3区和CA1区外侧部分均参与习得，而CA1区内测部分则不参与。
