ZJU 指数与美国 20-59 岁成年人肌少症风险相关：一项横断面研究。

The ZJU index is associated with the risk of sarcopenia in American adults aged 20-59: a cross-sectional study.

机构信息

Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Lipids Health Dis. 2024 Nov 26;23(1):389. doi: 10.1186/s12944-024-02373-w.

DOI:10.1186/s12944-024-02373-w

PMID:39593075

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11590360/

Abstract

BACKGROUND

The ZJU index is an innovative computational method which integrates BMI, FBG, TG, and ALT to AST ratio. It strongly correlates with measures of lipid metabolism and glucose intolerance. No researches have yet explored the relationship between the ZJU index and sarcopenia.

METHODS

We analyzed NHANES data from 2011 to 2018, dividing the ZJU index into quartiles. The association was investigated by adjusting for confounders using multivariable linear and logistic regression analysis. Results were visualized through RCS regression and threshold effect analyses. We conducted various subgroup and sensitivity analyses and plotted ROC curves to assess prediction efficacy, with the AUC as the measure of accuracy.

RESULTS

As the ZJU index increases, the prevalence of sarcopenia also rises. Following the control of potential confounders via logistic regression analysis, our research identified a distinct relationship between the ZJU index and sarcopenia, which was statistically significant (P < 0.001), with higher ZJU index values associated with increased risk (OR = 12.40, 95% CI: 8.46-18.17). Interaction analysis suggests that the relationship between the ZJU index and the risk of developing sarcopenia varies significantly between males and females across different ZJU index levels. ROC analysis for the ZJU index shows an AUC of 0.749.

CONCLUSIONS

The ZJU index significantly correlates with a heightened risk of sarcopenia in Americans, suggesting its potential as a predictive marker for sarcopenia.

摘要

背景

ZJU 指数是一种创新的计算方法，它将 BMI、FBG、TG 和 ALT 与 AST 的比值结合起来。它与脂质代谢和葡萄糖不耐受的测量指标密切相关。目前还没有研究探讨 ZJU 指数与肌肉减少症之间的关系。

方法

我们分析了 2011 年至 2018 年的 NHANES 数据，将 ZJU 指数分为四分位数。通过多变量线性和逻辑回归分析调整混杂因素后，研究了这种相关性。结果通过 RCS 回归和阈值效应分析进行可视化。我们进行了各种亚组和敏感性分析，并绘制了 ROC 曲线来评估预测效果，以 AUC 作为准确性的衡量标准。

结果

随着 ZJU 指数的增加，肌肉减少症的患病率也随之上升。通过逻辑回归分析控制潜在混杂因素后，我们的研究发现 ZJU 指数与肌肉减少症之间存在明显的关系，具有统计学意义（P<0.001），ZJU 指数值较高与风险增加相关（OR=12.40，95%CI：8.46-18.17）。交互分析表明，ZJU 指数与男性和女性在不同 ZJU 指数水平下发生肌肉减少症的风险之间的关系存在显著差异。ZJU 指数的 ROC 分析显示 AUC 为 0.749。