Xie Zuopu, Chen Xianpei, Xie Chunming, Yang Qi, Lin Hao
Department of Gastroenterology, Pingyang Hospital of Wenzhou Medical University, Wenzhou city, China.
Digestive Endoscopy Center, Pingyang Hospital of Wenzhou Medical University, Wenzhou city, China.
BMC Gastroenterol. 2024 Dec 18;24(1):458. doi: 10.1186/s12876-024-03553-9.
Based on triglyceride, body mass index (BMI), alanine aminotransferase/ aspartate aminotransferase ratio, fasting blood glucose, the ZJU index is proven to be a novel and effective parameter for screening NAFLD in Chinese. This study aims to evaluate the correlation between ZJU values and the risk of developing gallstones.
The data from the National Health and Nutrition Examination Survey (NHANES) database during the period from 2017 to 2020 were analyzed in this cross-sectional study. And 6155 participants were included to assess the correlation between the ZJU index and the formation of gallstones through multivariate logistic regression, receiver operating characteristic (ROC) curve, subgroup analysis, and restricted cubic spline regression (RCS) analyses.
In this population-based study, 6155 participants aged 18 years and older were included, among which, 671 had gallstones. Logistic regression and RCS regression analyses indicated a significant positive non-linearly correlation between the ZJU index and the prevalence of gallstones (OR = 1.044, 95% CI: 1.032, 1.056), with an inflection point of 40.6. Subgroup analysis further revealed a stronger correlation between the risk of developing gallstones and the ZJU index in females. ROC analysis indicated that the ZJU index (AUC = 0.653) can serve as a more robust predictor for developing gallstones compared to traditional indices, with a sensitivity of 55.9%, a specificity of 67.1% and a cutoff of 43.4.
This study provides evidence that elevated the ZJU index is correlated with an increased risk of developing gallstones.
基于甘油三酯、体重指数（BMI）、谷丙转氨酶/谷草转氨酶比值、空腹血糖，浙江大学（ZJU）指数已被证明是筛查中国非酒精性脂肪性肝病（NAFLD）的一种新颖且有效的参数。本研究旨在评估ZJU值与胆结石发生风险之间的相关性。
在这项横断面研究中，分析了2017年至2020年期间美国国家健康与营养检查调查（NHANES）数据库中的数据。纳入6155名参与者，通过多因素逻辑回归、受试者工作特征（ROC）曲线、亚组分析和限制性立方样条回归（RCS）分析来评估ZJU指数与胆结石形成之间的相关性。
在这项基于人群的研究中，纳入了6155名18岁及以上的参与者，其中671人患有胆结石。逻辑回归和RCS回归分析表明，ZJU指数与胆结石患病率之间存在显著的正非线性相关性（OR = 1.044，95%CI：1.032，1.056），拐点为40.6。亚组分析进一步显示，女性患胆结石的风险与ZJU指数之间的相关性更强。ROC分析表明，与传统指标相比，ZJU指数（AUC = 0.653）可作为预测胆结石发生的更可靠指标，敏感性为55.9%，特异性为67.1%，临界值为43.4。
本研究提供了证据表明ZJU指数升高与胆结石发生风险增加相关。
