帕金森病冻结步态的运动和非运动预测因素：一项回顾性队列研究。

Motor and non-motor predictors of freezing of gait in Parkinson's disease: A retrospective cohort study.

机构信息

Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western Ontario University, London, ON, Canada.

Department of Psychiatry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

出版信息

J Bodyw Mov Ther. 2024 Oct;40:1774-1781. doi: 10.1016/j.jbmt.2024.10.043. Epub 2024 Oct 15.

DOI:10.1016/j.jbmt.2024.10.043

PMID:39593523

Abstract

INTRODUCTION

Freezing of gait (FOG) is a debilitating episodic gait disorder that significantly reduces the quality of life (QoL) in patients with Parkinson's disease (PD). Diagnosing and treating FOG remains a major medical challenge. This study aimed to assess the correlation between FOG and both motor and non-motor clinical characteristics in patients with PD.

METHODS

In this retrospective cohort study, 112 patients with PD were divided into two groups using the New Freezing of Gait Questionnaire (NFOG-Q): one group with FOG (PD-FOG, 53 patients) and one group without FOG (PD-nFOG, 59 patients). The severity of PD and FOG was assessed using the Unified Parkinson's Disease Rating Scale (UPDRS), the Hoehn-Yahr (H-Y) staging system, and the NFOG-Q. The study also analyzed non-motor symptoms, including sleep disturbances, cognitive impairments, depression, anxiety, apathy, fatigue, and QoL.

RESULT

The prevalence of FOG was 47.3%. The PD-FOG group exhibited a longer duration of PD (P = 0.002), a higher H-Y stage indicating PD progression (P = 0.003), and elevated anxiety levels (P = 0.003) compared to the PD-nFOG group. According to binary logistic regression analysis, the higher H-Y stage (P = 0.022), anxiety level (P = 0.005), UPDRS part II (P = 0.001), and part III (P = 0.008) were significant predictors for the occurrence of FOG.

CONCLUSION

Patients with Parkinson's disease who have a higher Hoehn-Yahr (H-Y) stage, higher UPDRS score, and elevated levels of anxiety are more likely to experience FOG.

摘要

简介

冻结步态（FOG）是一种使人虚弱的间歇性步态障碍，会显著降低帕金森病（PD）患者的生活质量（QoL）。诊断和治疗 FOG 仍然是一个主要的医学挑战。本研究旨在评估 FOG 与 PD 患者的运动和非运动临床特征之间的相关性。

方法

在这项回顾性队列研究中，112 名 PD 患者使用新冻结步态问卷（NFOG-Q）分为两组：一组有 FOG（PD-FOG，53 名患者），一组无 FOG（PD-nFOG，59 名患者）。使用统一帕金森病评定量表（UPDRS）、Hoehn-Yahr（H-Y）分期系统和 NFOG-Q 评估 PD 和 FOG 的严重程度。该研究还分析了非运动症状，包括睡眠障碍、认知障碍、抑郁、焦虑、冷漠、疲劳和生活质量。

结果

FOG 的患病率为 47.3%。与 PD-nFOG 组相比，PD-FOG 组的 PD 持续时间更长（P=0.002），PD 进展的 H-Y 分期更高（P=0.003），焦虑水平更高（P=0.003）。根据二元逻辑回归分析，更高的 H-Y 分期（P=0.022）、焦虑水平（P=0.005）、UPDRS 第二部分（P=0.001）和第三部分（P=0.008）是发生 FOG 的显著预测因素。