不安腿综合征与帕金森病患者运动或其他非运动症状之间的相关性：一项观察性研究。
The correlation between RLS and motor or other non-motor symptoms of PD patients: an observational study.
作者信息
Chen Junfeng, Li Lan, Tian Xiuhua, Guo Xiaoyan
机构信息
Department of Neurology, the Affiliated Hospital of Southwest Medical University, Taiping Street, Jiangyang District, Luzhou, 646000, China.
出版信息
BMC Neurol. 2025 Jul 19;25(1):298. doi: 10.1186/s12883-025-04307-0.
BACKGROUND
Numerous studies have demonstrated restless legs syndrome (RLS) might worsen motor and non-motor symptoms in patients with Parkinson’s Disease (PD). However, research into the effects of concurrent RLS on the function of the autonomic nervous system remains limited. Our study particularly focused on its effects on the autonomic nervous system.
METHOD
From October 2022 to February 2025, 392 patients with PD were continuously included in our study. PD patients were categorized into those with RLS and those without RLS, based on the criteria established by the International Restless Legs Syndrome Study Group (IRLSSG). A variety of questionnaires were utilized to evaluate the severity of symptoms in PD patients, including the King’s Parkinson’s Disease Pain Scale (KPPS), Parkinson’s Disease Sleep Scale (PDSS), and the Scales for Outcomes in Parkinson’s Disease for Autonomic Dysfunction (SCOPA-AUT), among others.
RESULT
Our research included 98 patients (25.0%) who met the IRLSSG diagnostic criteria for RLS. The concurrent RLS in PD patients was significantly related to KPPS scores KPPS scores [OR = 1.049, 95%CI:1.007–1.093, = 0.021], thermoregulatory subscores [OR = 1.275, 95%CI:1.007–1.615, = 0.044] and PDSS scores [OR = 0.978, 95%CI:0.963–0.993, = 0.004]. Moreover, the Restless Leg Syndrome Rating Scale (RLSRS) scores in PD with RLS group were positively associated with Pittsburgh Sleep Quality Index (PSQI) scores [β = 0.312, 95%CI:0.031–0.683, = 0.032].
CONCLUSION
1.PD patients experiencing more severe pain symptoms, more severe sleep disorders, and more severe dysfunction of the thermoregulatory system were at a higher risk of developing RLS. Among these factors, pain score was the most effective predictor of concurrent RLS. 2. PD patients with RLS who had poorer sleep quality tended to have a more severe RLS.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1186/s12883-025-04307-0.
背景
大量研究表明，不安腿综合征（RLS）可能会加重帕金森病（PD）患者的运动和非运动症状。然而，关于并发RLS对自主神经系统功能影响的研究仍然有限。我们的研究特别关注其对自主神经系统的影响。
方法
从2022年10月至2025年2月，我们持续纳入了392例PD患者。根据国际不安腿综合征研究组（IRLSSG）制定的标准，将PD患者分为伴有RLS和不伴有RLS两组。使用了多种问卷来评估PD患者的症状严重程度，包括国王帕金森病疼痛量表（KPPS）、帕金森病睡眠量表（PDSS）以及帕金森病自主神经功能障碍结局量表（SCOPA-AUT）等。
结果
我们的研究纳入了98例（25.0%）符合IRLSSG RLS诊断标准的患者。PD患者并发RLS与KPPS评分[OR = 1.049，95%CI：1.007–1.093，P = 0.021]、体温调节子评分[OR = 1.275，95%CI：1.007–1.615，P = 0.044]和PDSS评分[OR = 0.978，95%CI：0.963–0.993，P = 0.004]显著相关。此外，伴有RLS的PD组的不安腿综合征评定量表（RLSRS）评分与匹兹堡睡眠质量指数（PSQI）评分呈正相关[β = 0.312，95%CI：0.031–0.683，P = 0.032]。
结论
1.经历更严重疼痛症状、更严重睡眠障碍和更严重体温调节系统功能障碍的PD患者发生RLS的风险更高。在这些因素中，疼痛评分是并发RLS最有效的预测指标。2.睡眠质量较差的伴有RLS的PD患者往往RLS更严重。
补充信息
在线版本包含可在10.11
Zotero 插件