Wu Yingying, Zhang Shen, Wang Jingyi, He Fan, Wei Haocheng, Chen Dongxiao, Wang Ying
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Foods. 2024 Nov 13;13(22):3624. doi: 10.3390/foods13223624.
The primary cause of postharvest loss in table grape fruit is attributed to gray mold, which is caused by . The present study confirmed the inhibitory effects of nystatin on the growth and development of , which led to a remarkable reduction in the severity of gray mold on table grape fruits. Furthermore, the application of nystatin disrupted the membrane permeability of , causing increased cellular leakage and cell death. In addition, the transcriptome analysis showed that the application of nystatin effectively modulated the transcriptional profile of genes involved in ribosome and mitochondrion biogenesis, as well as oxidoreductase activity, thereby disrupting the homeostasis of cellular organelles. Moreover, the nystatin treatment down-regulated genes associated with membrane trafficking, protein degradation by the ubiquitin-proteasome system, and the autophagy process, ultimately attenuating the pathogenicity of . Collectively, nystatin can be considered a viable agent for managing gray mold on table grape fruit.
鲜食葡萄采后损失的主要原因是灰霉病，其由……引起。本研究证实了制霉菌素对……生长发育的抑制作用，这使得鲜食葡萄果实上灰霉病的严重程度显著降低。此外，制霉菌素的施用破坏了……的膜通透性，导致细胞渗漏增加和细胞死亡。另外，转录组分析表明，制霉菌素的施用有效调节了参与核糖体和线粒体生物发生以及氧化还原酶活性的基因的转录谱，从而破坏了细胞器的稳态。而且，制霉菌素处理下调了与膜运输、泛素 - 蛋白酶体系统介导的蛋白质降解以及自噬过程相关的基因，最终减弱了……的致病性。总体而言，制霉菌素可被视为防治鲜食葡萄果实灰霉病的一种可行药剂。
