College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong 643000, China.
Division of Natural & Mathematical Sciences, LeMoyne-Owen College, Memphis, TN 38126, USA.
Cells. 2024 Nov 11;13(22):1870. doi: 10.3390/cells13221870.
Dishevelled (DVL) proteins precisely control Wnt signaling pathways with many effectors. While substantial research has advanced our understanding of DVL's role in Wnt pathways, key questions regarding its regulatory mechanisms and interactions remain unresolved. Herein, we present the recent advances and perspectives on how DVL regulates signaling. The experimentally determined conserved domain structures of DVL in conjunction with AlphaFold-predicted structures are used to understand the DVL's role in Wnt signaling regulation. We also summarize the role of DVL in various diseases and provide insights into further directions for research on the DVL-mediated signaling mechanisms. These findings underscore the importance of DVL as a pharmaceutical target or biological marker in diseases, offering exciting potential for future biomedical applications.
Dishevelled（DVL）蛋白通过多种效应物精确控制 Wnt 信号通路。虽然大量研究已经提高了我们对 DVL 在 Wnt 途径中的作用的理解，但关于其调节机制和相互作用的关键问题仍未得到解决。本文介绍了 DVL 调节信号的最新进展和观点。通过实验确定的 DVL 的保守结构域结构以及 AlphaFold 预测的结构用于理解 DVL 在 Wnt 信号转导调节中的作用。我们还总结了 DVL 在各种疾病中的作用，并为研究 DVL 介导的信号机制提供了进一步的方向。这些发现强调了 DVL 作为疾病中药物靶点或生物标志物的重要性，为未来的生物医学应用提供了令人兴奋的潜力。
