Rosa Alessio, Pujia Alberto Maria, Arcuri Claudio
Department of Chemical Science and Technologies, Dentistry, University of Rome Tor Vergata, 00133 Rome, Italy.
Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
Biomedicines. 2024 Nov 4;12(11):2522. doi: 10.3390/biomedicines12112522.
Topical applications have long been regarded as precise methods for delivering drugs to soft tissues, such as the periodontal ligament, as well as hard structures, including the alveolar bone and cementum. Recently, the combination of hyaluronic acid (HA) and ozone therapy has gained popularity as a supportive treatment for chronic inflammation, in addition to its established role in enhancing healing after dental procedures.
To gather the necessary research for our study, we conducted a systematic search across several databases, including PubMed, Google Scholar, and Ovid. Our study was registered under Prospero number CRD42024569641. The research, which began in June 2015 and concluded in May 2024, systematically examined the potential benefits of topical HA application in the management of both acute and chronic inflammatory diseases. Using relevant keywords and Medical Subject Headings, we selected 28 pertinent studies: three related to gingivitis, thirteen on chronic periodontitis, seven involving dental surgeries such as implants and sinus lifts, and three on oral ulcers.
The risk of bias among the analyzed studies was assessed using the RoB 2 tool. Regarding the randomization process, 75% of the studies exhibited a high risk of bias. However, all studies (100%) had a low risk of bias concerning allocation concealment. Only 25% of the studies adequately addressed performance bias, and another 25% reported all outcome data. Nevertheless, 85% of the included studies showed a low risk of reporting bias.
The results indicate that the use of topical HA in combination with ozone therapy is highly effective not only in promoting post-operative healing following dental procedures but also in providing positive outcomes for individuals dealing with chronic gingivitis, periodontal inflammation, and oral ulcers.
长期以来，局部应用一直被视为将药物输送到软组织（如牙周韧带）以及硬组织（包括牙槽骨和牙骨质）的精确方法。最近，透明质酸（HA）与臭氧疗法的联合应用作为慢性炎症的辅助治疗方法受到了广泛关注，此外，它在促进牙科手术后的愈合方面也发挥着既定作用。
为了收集我们研究所需的资料，我们在包括PubMed、谷歌学术和Ovid在内的多个数据库中进行了系统检索。我们的研究在国际前瞻性注册系统（Prospero）中注册，注册号为CRD42024569641。这项始于2015年6月并于2024年5月结束的研究，系统地考察了局部应用HA在治疗急慢性炎症性疾病方面的潜在益处。我们使用相关关键词和医学主题词，筛选出28项相关研究：3项与牙龈炎有关，13项关于慢性牙周炎，7项涉及种植牙和上颌窦提升等牙科手术，3项关于口腔溃疡。
使用RoB 2工具评估了所分析研究中的偏倚风险。在随机化过程方面，75%的研究显示出高偏倚风险。然而，所有研究（100%）在分配隐藏方面的偏倚风险较低。只有25%的研究充分解决了实施偏倚问题，另有25%的研究报告了所有结局数据。尽管如此，85%的纳入研究显示出低报告偏倚风险。
结果表明，局部应用HA与臭氧疗法相结合不仅在促进牙科手术后的愈合方面非常有效，而且对于患有慢性牙龈炎、牙周炎和口腔溃疡的个体也能产生积极效果。
