Hatchell D L, Reiser H J, Bresnahan J F, Whitworth U G
Lab Anim Sci. 1986 Feb;36(1):37-40.
Experimental diabetes mellitus can be induced chemically in many species of animals with streptozotocin or alloxan. However, the cat is known to be resistant to the diabetogenic effect of streptozotocin. The purpose of this study was to find the optimal dose and rate of injection of alloxan to consistently produce hyperglycemia (blood sugar levels greater than 300 mg/dl) in cats. Alloxan was administered to 22 cats at various concentrations (50, 100 and 150 mg/kg) and different rates of injection (0.5, 1.0 and 1.5 ml/min). No hyperglycemic effect was observed at any of the concentrations or different rates of injection. Cats receiving high concentrations and/or high rates of injection of alloxan died due to kidney damage. The results of this study suggest that the cat is resistant to the diabetogenic effect of alloxan, but is susceptible to its toxic side effects.
实验性糖尿病可通过链脲佐菌素或四氧嘧啶在许多动物物种中化学诱导产生。然而，已知猫对链脲佐菌素的致糖尿病作用具有抗性。本研究的目的是找出能使猫持续产生高血糖（血糖水平高于300mg/dl）的四氧嘧啶的最佳剂量和注射速率。以不同浓度（50、100和150mg/kg）和不同注射速率（0.5、1.0和1.5ml/min）给22只猫注射四氧嘧啶。在任何浓度或不同注射速率下均未观察到高血糖效应。接受高浓度和/或高注射速率四氧嘧啶的猫因肾损伤而死亡。本研究结果表明，猫对四氧嘧啶的致糖尿病作用具有抗性，但易受其毒性副作用的影响。
