Castiñeiras M J, Boronat A, Itarte E, Guinovart J J, Rosell-Pérez M
Rev Esp Fisiol. 1978 Dec;34(4):385-8.
The effect of diabetogenic agents, alloxan and streptozotocin, in frogs has been studied. These drugs were administered to the animals by injection into the dorsal lymph sac. Alloxan did not exert any effect at non-lethal doses. At 300 mg/kg alloxan caused death of most of the animals in an hyperglycemic state in less than 72 hours. Streptozotocin at doses lower than 1 g/kg was ineffective. At 1.5 g/kg, a non-lethal dose, about half of the animals became diabetic.
已经研究了致糖尿病药物四氧嘧啶和链脲佐菌素对青蛙的作用。这些药物通过注射到背部淋巴囊给予动物。在非致死剂量下，四氧嘧啶没有产生任何作用。在300毫克/千克时，四氧嘧啶在不到72小时内使大多数动物在高血糖状态下死亡。低于1克/千克的链脲佐菌素剂量无效。在1.5克/千克（非致死剂量）时，约一半的动物患糖尿病。
