类器官在皮肤衰老研究中的应用:机制、应用及见解。

Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights.

机构信息

Peking Union Medical College Hospital (Dongdan Campus), No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China.

出版信息

Biomolecules. 2024 Nov 12;14(11):1436. doi: 10.3390/biom14111436.

Abstract

Organoids have emerged as transformative tools in biomedical research, renowned for their ability to replicate the complexity construct of human tissues. Skin aging is a multifaceted biological process, influenced by both intrinsic factors and extrinsic factors. Traditional models for studying skin aging often fall short in capturing the intricate dynamics of human skin. In contrast, skin organoids offer a more physiologically relevant system, reflecting the structural and functional characteristics of native skin. These characteristics make skin organoids highly suitable for studying the mechanisms of skin aging, identifying novel therapeutic targets, and testing anti-aging interventions. Despite their promise, challenges such as limited scalability, reproducibility, and ethical considerations remain. Addressing these hurdles through interdisciplinary research and technological advancements will be essential to maximizing the potential of skin organoids for dermatological research and personalized anti-aging therapies.

摘要

类器官在生物医学研究中已经成为一种变革性的工具,它们能够复制人体组织的复杂结构,这一特性为人所熟知。皮肤衰老过程是一个多方面的生物学过程,受到内在因素和外在因素的影响。传统的皮肤衰老研究模型往往无法捕捉到人类皮肤的复杂动态。相比之下,皮肤类器官提供了一个更具生理相关性的系统,反映了天然皮肤的结构和功能特征。这些特性使皮肤类器官非常适合研究皮肤衰老的机制、确定新的治疗靶点以及测试抗衰老干预措施。尽管具有这些优势,但仍然存在一些挑战,如规模有限、可重复性和伦理考虑等。通过跨学科研究和技术进步来解决这些难题,对于最大限度地发挥皮肤类器官在皮肤学研究和个性化抗衰老疗法中的潜力至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de0/11591780/1d50f9303ab7/biomolecules-14-01436-g001.jpg

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