Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, No. 2025, Chengluo Avenue, Longquanyi District, Chengdu 610106, China.
Int J Mol Sci. 2024 Nov 11;25(22):12092. doi: 10.3390/ijms252212092.
Plant-derived exosome-like nanoparticles (PELNs) are a type of membranous vesicle isolated from plant tissues. They contain proteins, lipids, nucleic acids, and other components. PELNs are involved in the defensive response to pathogen attacks by exerting anti-inflammatory, antiviral, antifibrotic, and antitumor effects through the substances they contain. Most PELNs are edible and can be used as carriers for delivering specific drugs without toxicity and side effects, making them a hot topic of research. Sources of PELNs are abundantly, and they can be produced in high yields, with a low risk of developing immunogenicity in vivo. This paper summarizes the formation, isolation, and purification methods; physical properties; and composition of PELNs through a comprehensive literature search. It also analyzes the biomedical applications of PELNs, as well as future research directions. This paper provides new ideas and methods for future research on PELNs.
植物来源的外泌体样纳米颗粒（PELN）是从植物组织中分离得到的一种膜囊泡。它们包含蛋白质、脂质、核酸和其他成分。PELN 通过其所含物质发挥抗炎、抗病毒、抗纤维化和抗肿瘤作用，参与对病原体攻击的防御反应。大多数 PELN 是可食用的，可以作为载体来递送特定的药物，而不会产生毒性和副作用，因此成为研究的热点。PELN 的来源丰富，产量高，在体内产生免疫原性的风险低。本文通过全面的文献检索，总结了 PELN 的形成、分离和纯化方法、物理性质和组成。还分析了 PELN 的生物医学应用以及未来的研究方向。本文为未来 PELN 的研究提供了新的思路和方法。
