Department of Immunology, The Fourth Military Medical University, Xi'an 710032, China.
Int J Mol Sci. 2024 Nov 14;25(22):12223. doi: 10.3390/ijms252212223.
Metabolic reprogramming of immune cells within the tumor microenvironment (TME) plays a pivotal role in shaping tumor progression and responses to therapy. The intricate interplay between tumor cells and immune cells within this ecosystem influences their metabolic landscapes, thereby modulating the immune evasion tactics employed by tumors and the efficacy of immunotherapeutic interventions. This review delves into the metabolic reprogramming that occurs in tumor cells and a spectrum of immune cells, including T cells, macrophages, dendritic cells, and myeloid-derived suppressor cells (MDSCs), within the TME. The metabolic shifts in these cell types span alterations in glucose, lipid, and amino acid metabolism. Such metabolic reconfigurations can profoundly influence immune cell function and the mechanisms by which tumors evade immune surveillance. Gaining a comprehensive understanding of the metabolic reprogramming of immune cells in the TME is essential for devising novel cancer therapeutic strategies. By targeting the metabolic states of immune cells, it is possible to augment their anti-tumor activities, presenting new opportunities for immunotherapeutic approaches. These strategies hold promise for enhancing treatment outcomes and circumventing the emergence of drug resistance.
肿瘤微环境（TME）中免疫细胞的代谢重编程在塑造肿瘤进展和对治疗的反应方面起着关键作用。肿瘤细胞与生态系统内免疫细胞之间的复杂相互作用影响它们的代谢景观，从而调节肿瘤采用的免疫逃逸策略和免疫治疗干预的效果。这篇综述深入探讨了 TME 中肿瘤细胞和一系列免疫细胞（包括 T 细胞、巨噬细胞、树突状细胞和髓系来源的抑制细胞（MDSC））发生的代谢重编程。这些细胞类型的代谢转变包括葡萄糖、脂质和氨基酸代谢的改变。这种代谢重构可以深刻影响免疫细胞的功能以及肿瘤逃避免疫监视的机制。全面了解 TME 中免疫细胞的代谢重编程对于制定新的癌症治疗策略至关重要。通过靶向免疫细胞的代谢状态，可以增强它们的抗肿瘤活性，为免疫治疗方法提供新的机会。这些策略有望改善治疗效果并避免耐药性的出现。
