Department of Food Science & Technology, University of Patras, GR-30100 Agrinio, Greece.
Department of Chemistry, University of Patras, GR-26504 Patras, Greece.
Int J Mol Sci. 2024 Nov 15;25(22):12264. doi: 10.3390/ijms252212264.
Antibacterial coatings based on quaternary ammonium compounds (QACs) have been widely investigated in controlled release applications. Quaternary ammonium compounds are low-cost and easily accessible disinfectants that have been extensively used, especially after the COVID-19 outbreak. There has been a growing interest in developing a clearer understanding of various aspects that need to be taken into account for the design of quaternary ammonium compounds to be used in the biomedical field. In this contribution, we outline the mechanism of action of those materials as well as the key design parameters associated with their structure and antibacterial activity. Moreover, emphasis has been placed on the type of antibacterial coatings based on QACs and their applications in the biomedical field. A brief outlook on future research guidelines for the development of dual-function antibacterial coatings is also discussed.
基于季铵化合物（QACs）的抗菌涂层在控制释放应用中得到了广泛研究。季铵化合物是低成本且易于获得的消毒剂，已被广泛使用，尤其是在 COVID-19 爆发之后。人们越来越有兴趣深入了解在设计用于生物医学领域的季铵化合物时需要考虑的各个方面。在本贡献中，我们概述了这些材料的作用机制以及与其结构和抗菌活性相关的关键设计参数。此外，还重点介绍了基于 QAC 的抗菌涂层的类型及其在生物医学领域的应用。还简要讨论了开发双功能抗菌涂层的未来研究指南。
