Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Florida Campus, Roodepoort 1710, South Africa.
Int J Mol Sci. 2024 Nov 15;25(22):12276. doi: 10.3390/ijms252212276.
Type 2 diabetes (T2D) is characterised by insulin resistance and leads to hyperglycaemia. Its prevalence and associated complications continue to rise exponentially, despite the existence of pharmaceutical drugs, and this has prompted research into exploring safer herbal remedies. (purslane) has been investigated in animal and clinical trials to explore its effects on diabetes, yielding conflicting results. This study aimed to evaluate the effects of purslane on inflammation and oxidative stress in diabetes mellitus. We conducted a comprehensive literature search on Scopus PubMed, and through a manual bibliographical search to find relevant studies from inception to 13 September 2024. The search terms included purslane, , and type 2 diabetes mellitus. Of the 38 retrieved studies, 12 were considered relevant and underwent critical review. Evidence from rodent studies showed decreased inflammatory markers such as interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), nuclear factor kappa-beta (NF-κβ), and C-reactive (CRP), while interleukin-10 (IL-10) was increased after intervention with purslane. The markers of oxidative stress such as superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) levels increased, thiobarbituric acid reactive substances (TBARS), reactive oxygen species (ROS) and malondialdehyde (MDA) decreased. Notably, the evidence from clinical trials showed a significant reduction in NF-κβ and CRP after purslane treatment; however, no effect was observed on MDA and TAC. The evidence gathered in this study suggests that purslane exerts anti-inflammatory properties by downregulating NF-κβ, thus suppressing the production of associated pro-inflammatory cytokines. Therefore, purslane may be used as an antioxidant and inflammatory agent for diabetes. However, further clinical evidence with a broader population is required to validate the therapeutic properties of purslane in diabetes.
2 型糖尿病（T2D）的特征是胰岛素抵抗，导致高血糖。尽管存在药物治疗，但它的患病率和相关并发症仍在呈指数级增长，这促使人们研究更安全的草药疗法。马齿苋已在动物和临床试验中进行了研究，以探索其对糖尿病的影响，但结果相互矛盾。本研究旨在评估马齿苋对糖尿病炎症和氧化应激的影响。我们在 Scopus、PubMed 上进行了全面的文献检索，并通过手动文献检索，从研究开始到 2024 年 9 月 13 日，查找了相关研究。检索词包括马齿苋、糖尿病和 2 型。在检索到的 38 项研究中，有 12 项被认为是相关的，并进行了批判性评价。来自啮齿动物研究的证据表明，炎症标志物如白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、核因子 kappa-β（NF-κβ）和 C 反应蛋白（CRP）降低，而白细胞介素-10（IL-10）在马齿苋干预后增加。氧化应激标志物如超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GPx）和总抗氧化能力（TAC）水平升高，硫代巴比妥酸反应物质（TBARS）、活性氧（ROS）和丙二醛（MDA）减少。值得注意的是，临床试验的证据表明，马齿苋治疗后 NF-κβ和 CRP 显著降低；然而，MDA 和 TAC 没有影响。本研究收集的证据表明，马齿苋通过下调 NF-κβ发挥抗炎作用，从而抑制相关促炎细胞因子的产生。因此，马齿苋可能被用作糖尿病的抗氧化和抗炎剂。然而，需要更多具有更广泛人群的临床证据来验证马齿苋在糖尿病中的治疗特性。
