Ophthalmology Discipline, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Clinical Hospital for Ophthalmological Emergencies, 010464 Bucharest, Romania.
Int J Mol Sci. 2024 Nov 19;25(22):12400. doi: 10.3390/ijms252212400.
Glaucoma is a main cause of irreversible blindness worldwide, with a high impact on productivity and quality of life. The mechanical and ischemic theories are currently the most recognized pathophysiological pathways that explain the neurodegeneration of retinal nerve fibers in glaucoma. In this narrative review, aspects of ischemia in glaucoma are discussed, including vascular dysregulation, retinal ischemia signaling pathways, roles of vascular endothelial growth factors, and future research and therapeutic directions. In conclusion, a better understanding of the ischemic processes in glaucoma may lead to innovative treatment options and improved management and follow-up of our patients.
青光眼是全球范围内导致不可逆性失明的主要原因，对生产力和生活质量有重大影响。机械和缺血理论是目前最被认可的解释青光眼视网膜神经纤维变性的病理生理学途径。在本叙述性综述中，讨论了青光眼的缺血方面，包括血管失调、视网膜缺血信号通路、血管内皮生长因子的作用，以及未来的研究和治疗方向。总之，更好地了解青光眼的缺血过程可能会带来创新性的治疗选择，并改善我们对患者的管理和随访。
