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LncRNA MSTRG.20890.1 在绒山羊毛囊发育中的作用。

Role of LncRNA MSTRG.20890.1 in Hair Follicle Development of Cashmere Goats.

机构信息

College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China.

Key Laboratory of Mutton Sheep Genetics and Breeding, Ministry of Agriculture, Hohhot 010018, China.

出版信息

Genes (Basel). 2024 Oct 29;15(11):1392. doi: 10.3390/genes15111392.

DOI:10.3390/genes15111392
PMID:39596592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11593464/
Abstract

BACKGROUND

The cashmere goat is a biological resource that mainly produces cashmere. Cashmere has a soft hand feel and good luster, with high economic value. The quality and yield of cashmere are determined by the process of hair follicle development during the embryonic period.

METHODS

In this study, the skin of the Inner Mongolia cashmere goat at different embryonic stages (45, 55, 65, and 75d) was collected, and the differentially expressed lncRNA MSTRG.20890.1 at 75d was obtained by screening. Dual luciferase reporter gene system, qRT-PCR, and EDU experiments were used to verify further the regulatory role and molecular mechanism of the lncRNA in dermal fibroblasts.

RESULTS

Based on the transcriptome database of Inner Mongolia cashmere goat skin at different embryonic stages, which was previously constructed by our group, according to the characteristics of hair follicle development in the embryonic stage, we screened out the lncRNA MSTRG.20890.1 that was down-expressed on the 75-SHFINI day of the embryonic stage. We found that lncRNA MSTRG.20890.1 was mainly located in the cytoplasm of cells, and it could inhibit the proliferation and directional migration of dermal fibroblasts through the chi-miR-24-3p/ADAMTS3 signaling axis, thereby inhibiting the formation of dermal papilla structure at embryonic stage.

CONCLUSIONS

This study revealed that lncRNA MSTRG.20890.1 regulated secondary hair follicle morphogenesis and development in cashmere goats through the chi-miR-24-3p/ADAMTS3 signaling axis.

摘要

背景

绒山羊是一种主要生产羊绒的生物资源。羊绒手感柔软、光泽好，具有较高的经济价值。羊绒的质量和产量取决于胚胎期毛囊发育过程。

方法

本研究采集不同胚胎期（45、55、65 和 75d）内蒙古绒山羊皮肤，通过筛选获得 75d 时差异表达的 lncRNA MSTRG.20890.1。双荧光素酶报告基因系统、qRT-PCR 和 EDU 实验进一步验证了该 lncRNA 在真皮成纤维细胞中的调控作用及其分子机制。

结果

基于本课题组前期构建的内蒙古绒山羊不同胚胎期皮肤转录组数据库，根据胚胎期毛囊发育的特点，筛选出在胚胎期 75-SHFINI 日表达下调的 lncRNA MSTRG.20890.1。研究发现，lncRNA MSTRG.20890.1 主要位于细胞的细胞质中，它可以通过 chi-miR-24-3p/ADAMTS3 信号轴抑制真皮成纤维细胞的增殖和定向迁移，从而抑制胚胎期真皮乳头结构的形成。

结论

本研究揭示了 lncRNA MSTRG.20890.1 通过 chi-miR-24-3p/ADAMTS3 信号轴调节绒山羊次级毛囊形态发生和发育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/aeb85ac63a57/genes-15-01392-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/23025c31f6d4/genes-15-01392-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/ad462ffe8499/genes-15-01392-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/6c3d2e920ce1/genes-15-01392-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/f92c21992448/genes-15-01392-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/d3327a8efdd8/genes-15-01392-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/3bef03ad90ad/genes-15-01392-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/aeb85ac63a57/genes-15-01392-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/23025c31f6d4/genes-15-01392-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/ad462ffe8499/genes-15-01392-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/6c3d2e920ce1/genes-15-01392-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/f92c21992448/genes-15-01392-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/d3327a8efdd8/genes-15-01392-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/3bef03ad90ad/genes-15-01392-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2e/11593464/aeb85ac63a57/genes-15-01392-g007.jpg

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